Symbol
Name
ID

Irf1
interferon regulatory factor 1
MGI:96590

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Asthma
Disease(s) Associated with IRF1	Asthma
asthma

Mouse Phenotypes

immune system phenotype

abnormal T cell proliferation

abnormal thymus cell ratio

increased double-positive T cell number

increased B-1 B cell number

decreased NK cell number

abnormal T cell number

increased T-helper 2 cell number

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

abnormal T cell morphology

abnormal splenocyte morphology

abnormal lymphocyte physiology

abnormal immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal macrophage physiology

decreased circulating interferon-gamma level

increased circulating interferon-gamma level

abnormal circulating interleukin-10 level

increased circulating interleukin-13 level

decreased circulating interleukin-2 level

increased circulating interleukin-3 level

abnormal circulating interleukin-4 level

increased circulating interleukin-4 level

increased circulating interleukin-5 level

increased circulating interleukin-6 level

abnormal cytokine level

abnormal immune system morphology

abnormal immune system physiology

decreased interferon-alpha secretion

decreased interferon-beta secretion

decreased interferon-gamma secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

decreased susceptibility to induced arthritis

abnormal response to infection

increased susceptibility to Herpesvirales infection

increased susceptibility to Poxviridae infection

Availability

Mouse Genotype

Irf1^M1Btlr/Irf1^M1Btlr

Irf1^m2Btlr/Irf1^m2Btlr

Irf1^M3Btlr/Irf1^M3Btlr

Irf1^tm1Cwe/Irf1^tm1Cwe

Irf1^tm1Mak/Irf1^tm1Mak

Irf1^M1Btlr/Irf1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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