|
Symbol Name ID |
Il1b
interleukin 1 beta MGI:96543 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Leukocytosis |
Leukopenia |
Sinusitis |
Chronic sinusitis |
Pericarditis |
Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Peritoneal abscess |
Subacute progressive viral hepatitis |
Pancreatitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Eczematoid dermatitis |
Discoid lupus rash |
Malar rash |
Recurrent pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Autoimmunity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with IL1B | |||||||||||||||||||||||||||||||||||||||||||||
| asthma | |||||||||||||||||||||||||||||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||||||||||||||||||||||||||||
| hepatocellular carcinoma | |||||||||||||||||||||||||||||||||||||||||||||
| IgA glomerulonephritis | |||||||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer | |||||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia | |||||||||||||||||||||||||||||||||||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | immune system phenotype |
abnormal lymphocyte physiology |
abnormal macrophage physiology |
decreased circulating interleukin-1 beta level |
decreased susceptibility to type IV hypersensitivity reaction |
decreased interferon-gamma secretion |
decreased interleukin-1 beta secretion |
decreased interleukin-2 secretion |
decreased interleukin-4 secretion |
abnormal interleukin-6 secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to experimental autoimmune myasthenia gravis |
decreased acute inflammation |
decreased inflammatory response |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
decreased susceptibility to Togaviridae infection induced morbidity/mortality |
decreased susceptibility to Togaviridae infection |
decreased susceptibility to viral infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||
| Il1btm1Dch/Il1btm1Dch | * | |||||||||||||||||||
| Il1btm1Lvp/Il1btm1Lvp | * | |||||||||||||||||||
| Il1btm1Yiw/Il1btm1Yiw | ||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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