Symbol
Name
ID

Il13
interleukin 13
MGI:96541

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cutaneous mastocytosis	Allergic rhinitis	Conjunctivitis	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess	Eczematoid dermatitis	Atopic dermatitis	Recurrent skin infections	Asthma
Disease(s) Associated with IL13	Cutaneous mastocytosis	Allergic rhinitis	Conjunctivitis	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess	Eczematoid dermatitis	Atopic dermatitis	Recurrent skin infections	Asthma
asthma
atopic dermatitis
mastocytosis
pancreatic cancer

Mouse Phenotypes

immune system phenotype

abnormal dendritic cell differentiation

ileum inflammation

abnormal T-helper 2 cell differentiation

decreased eosinophil cell number

increased eosinophil cell number

cutaneous mastocytosis

decreased T-helper 2 cell number

increased T-helper 2 cell number

decreased macrophage cell number

abnormal leukocyte physiology

impaired eosinophil recruitment

impaired neutrophil recruitment

decreased IgE level

increased IgE level

decreased IgG1 level

increased IgG1 level

increased IgG2a level

increased IgG2b level

decreased IgG level

increased IgM level

abnormal T-helper 2 physiology

abnormal macrophage physiology

abnormal splenocyte physiology

decreased circulating interleukin-13 level

abnormal chemokine level

abnormal immune system physiology

abnormal dendritic cell antigen presentation

abnormal type I hypersensitivity reaction

increased susceptibility to type I hypersensitivity reaction

abnormal antigen presentation

decreased interferon-gamma secretion

increased interferon-gamma secretion

abnormal interleukin secretion

decreased interleukin-10 secretion

decreased interleukin-13 secretion

increased interleukin-13 secretion

abnormal interleukin-4 secretion

decreased interleukin-4 secretion

increased interleukin-4 secretion

decreased interleukin-5 secretion

decreased interleukin-9 secretion

decreased susceptibility to autoimmune disorder

decreased susceptibility to experimental autoimmune encephalomyelitis

granulomatous inflammation

decreased inflammatory response

respiratory system inflammation

dermatitis

abnormal susceptibility to infection

decreased susceptibility to bacterial infection

decreased susceptibility to parasitic infection induced morbidity/mortality

increased susceptibility to parasitic infection induced morbidity/mortality

decreased susceptibility to parasitic infection

increased susceptibility to parasitic infection

abnormal response to transplant

increased length of allograft survival

Availability

Mouse Genotype

Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm

Il13^tm1.1Anjm/Il13^tm1.1Anjm

Il13^tm1Anjm/Il13^tm1Anjm

Il13^tm2Anjm/Il13^tm2Anjm

Tg(KRT5-tTA)1216Glk/0
Tg(tetO-Il13)1Tazh/0

Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0

Tg(Scgb1a1-Il13)2Eli/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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