|
Symbol Name ID |
Il10
interleukin 10 MGI:96537 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Increased circulating IgG level |
Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Decreased circulating antibody level |
Paraproteinemia |
Leukocytosis |
Leukopenia |
Impaired lymphocyte transformation with phytohemagglutinin |
Abnormal granulocyte morphology |
Abnormal basophil morphology |
Abnormality of neutrophils |
Granulomatosis |
Hemophagocytosis |
Leukemia |
Ph-positive acute lymphoblastic leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Sinusitis |
Severe periodontitis |
Stomatitis |
Conjunctivitis |
Keratoconjunctivitis sicca |
Pericarditis |
Lymphadenopathy |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
Gastrointestinal inflammation |
Recurrent gastroenteritis |
Peritoneal abscess |
Acute hepatitis |
Chronic hepatitis |
Subacute progressive viral hepatitis |
Chronic otitis media |
Keratitis |
Episcleritis |
Uveitis |
Iridocyclitis |
Inflammatory abnormality of the eye |
Epididymitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Fasciitis |
Inflammatory abnormality of the skin |
Eczematoid dermatitis |
Erythema nodosum |
Discoid lupus rash |
Maculopapular exanthema |
Malar rash |
Myositis |
Pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Cryoglobulinemia |
Autoimmunity |
Anti-citrullinated protein antibody positivity |
Antineutrophil antibody positivity |
Cytoplasmic antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Platelet antibody positive |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Asthma |
Recurrent infections |
| Disease(s) Associated with IL10 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| aggressive periodontitis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| asthma | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| autoimmune thrombocytopenic purpura | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Behcet's disease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| chronic myeloid leukemia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| factor VIII deficiency | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| graft-versus-host disease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| granulomatosis with polyangiitis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| lymphoplasmacytic lymphoma | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sjogren's syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia |
| Mouse Phenotypes | immune system phenotype |
decreased T cell proliferation |
increased susceptibility to induced colitis |
intestinal inflammation |
large intestinal inflammation |
cecum inflammation |
colitis |
small intestinal inflammation |
peritoneal inflammation |
increased thymus weight |
thymus hyperplasia |
pancreas inflammation |
periinsulitis |
spleen hyperplasia |
abnormal myelopoiesis |
increased granulocyte number |
increased myeloid dendritic cell number |
abnormal lymphocyte cell number |
increased plasma cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
increased T cell number |
abnormal leukocyte morphology |
abnormal myeloid leukocyte morphology |
decreased spleen iron level |
decreased spleen red pulp amount |
increased IgE level |
increased IgG1 level |
increased IgG2a level |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal regulatory T cell physiology |
increased circulating interferon-gamma level |
increased circulating interleukin-1 alpha level |
increased circulating interleukin-1 beta level |
decreased circulating interleukin-10 level |
increased circulating interleukin-12 level |
abnormal circulating interleukin-12b level |
increased circulating interleukin-17 level |
increased circulating interleukin-2 level |
abnormal circulating interleukin-6 level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal cytokine level |
abnormal chemokine level |
abnormal interferon level |
abnormal interleukin level |
abnormal tumor necrosis factor level |
abnormal lymph node morphology |
abnormal immune system physiology |
abnormal Langerhans cell physiology |
abnormal type IV hypersensitivity reaction |
increased susceptibility to type IV hypersensitivity reaction |
abnormal level of surface class II molecules |
abnormal hypersensitivity reaction |
abnormal cytokine secretion |
increased interferon-gamma secretion |
decreased interleukin-10 secretion |
abnormal inflammatory response |
increased susceptibility to endotoxin shock |
chronic inflammation |
liver inflammation |
lung inflammation |
abnormal innate immunity |
abnormal response to infection |
increased susceptibility to bacterial infection |
decreased susceptibility to parasitic infection |
increased susceptibility to parasitic infection |
decreased length of allograft survival |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm1.1Roer/Il10tm1.1Roer | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm1Cgn/Il10tm1Cgn | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm1Mhry/Il10tm1Mhry | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(IL2-Il10)1Kro/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(INS-Il10)#Sar/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm1Roer/Il10tm1Roer Tg(Cd4-cre)1Cwi/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm1Roer/Il10tm1Roer Foxp3tm4(YFP/icre)Ayr/Y (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Il10tm1Roer/Il10tm1Roer (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm2Roer/Il10tm2Roer Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il10tm2Roer/Il10tm2Roer Tg(Cd4-cre)1Cwi/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/14/2024 MGI 6.23 |
|
|
|
||
Analysis Tools