Symbol
Name
ID

Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
MGI:96534

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased B cell proliferation

abnormal T cell proliferation

decreased T cell proliferation

increased T cell proliferation

abnormal B cell differentiation

increased immature B cell number

arrested B cell differentiation

abnormal positive T cell selection

increased eosinophil cell number

increased neutrophil cell number

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased lymphocyte cell number

increased monocyte cell number

abnormal B cell physiology

decreased IgM level

abnormal T-helper 1 physiology

abnormal lymph node cell ratio

abnormal professional antigen presenting cell physiology

abnormal dendritic cell antigen presentation

decreased susceptibility to type IV hypersensitivity reaction

abnormal antigen presentation

abnormal antigen presentation via MHC class II

abnormal level of surface class II molecules

defective assembly of class II molecules

decreased interferon-gamma secretion

decreased interleukin-2 secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

increased susceptibility to experimental autoimmune encephalomyelitis

Availability

Mouse Genotype

Cd74^em1(IMPC)H/Cd74^em1(IMPC)H

Cd74^tm1Doi/Cd74^tm1Doi

Cd74^tm1Eae/Cd74^tm1Eae

Cd74^tm1Liz/Cd74^tm1Liz

Cd74^tm2Liz/Cd74^tm2Liz

Cd74^tm2Liz/Cd74^tm1Liz

Cd19^tm1(cre)Cgn/Cd19⁺
Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai}/Gt(ROSA)26Sor⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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