Symbol
Name
ID

Hmox1
heme oxygenase 1
MGI:96163

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Splenic rupture
Disease(s) Associated with HMOX1	Splenic rupture
factor VIII deficiency

Mouse Phenotypes

increased splenocyte proliferation

enlarged spleen

spleen hyperplasia

increased granulocyte number

abnormal leukocyte cell number

increased B cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased macrophage cell number

increased macrophage cell number

abnormal splenic cell ratio

increased circulating tumor necrosis factor level

abnormal lymph node cell ratio

enlarged lymph nodes

decreased interferon-beta secretion

increased interferon-gamma secretion

decreased interleukin-1 beta secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

increased susceptibility to experimental autoimmune encephalomyelitis

chronic inflammation

decreased inflammatory response

increased inflammatory response

liver inflammation

glomerulonephritis

lung inflammation

decreased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to parasitic infection induced morbidity/mortality

increased susceptibility to parasitic infection

decreased susceptibility to Paramyxoviridae infection

Availability

Mouse Genotype

Hmox1^tm1.2Gkl/Hmox1^tm1.2Gkl

Hmox1^tm1Mlee/Hmox1^tm1Mlee

Hmox1^tm1Poss/Hmox1^tm1Poss

Hmox1^tm1.1Gkl/Hmox1^tm1.1Gkl
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Hmox1^tm1.1Hes/Hmox1^tm1.1Hes
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23