Symbol
Name
ID

Fas
Fas cell surface death receptor
MGI:95484

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal lymphocyte apoptosis

Decreased lymphocyte apoptosis

Increased circulating IgA level

Increased circulating IgE level

Decreased circulating IgG level

Increased circulating IgG level

Decreased circulating total IgM

Increased circulating IgM level

Decreased specific anti-polysaccharide antibody level

Increased circulating antibody level

Reduced delayed hypersensitivity

Autoimmune hemolytic anemia

Eosinophilia

Neutropenia in presence of anti-neutropil antibodies

Increased B cell count

Decreased proportion of CD4-positive helper T cells

Abnormal proportion of CD4-positive T cells

Abnormal proportion of CD8-positive T cells

Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells

Increased proportion of HLA DR+ T cells

Lymphocytosis

Lymphopenia

Leukocytosis

Leukopenia

Abnormal granulocyte morphology

Abnormal basophil morphology

Ph-positive acute lymphoblastic leukemia

Acute myeloid leukemia

Chronic myelogenous leukemia

Myeloproliferative disorder

Autoimmune thrombocytopenia

Sinusitis

Chronic sinusitis

Recurrent aphthous stomatitis

Pericarditis

Lymphadenopathy

Chronic noninfectious lymphadenopathy

Follicular hyperplasia

Splenomegaly

Hepatosplenomegaly

Hypersplenism

Colitis

Helicobacter pylori infection

Hepatitis

Pancreatitis

Thyroiditis

Uveitis

Glomerulonephritis

Lupus nephritis

Nephritis

Abnormality of the immune system

Abnormal circulating interleukin concentration

Increased circulating interleukin 10 concentration

Increased circulating interleukin 18 concentration

Discoid lupus rash

Malar rash

Panniculitis

Recurrent pneumonia

Serositis

Decreased circulating complement C3 concentration

Decreased circulating complement C4 concentration

Autoimmunity

Anti-citrullinated protein antibody positivity

Anti-smooth muscle antibody positivity

Antineutrophil antibody positivity

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Anti-La/SS-B antibody positivity

Anti-Sm antibody positivity

Anti-U1 ribonucleoprotein antibody positivity

Antiphospholipid antibody positivity

Platelet antibody positive

Rheumatoid factor positive

Systemic lupus erythematosus

Asthma

Nontuberculous mycobacterial pulmonary infection

Recurrent Burkholderia cepacia infections

Recurrent Haemophilus influenzae infections

Recurrent Staphylococcus aureus infections

Recurrent Aspergillus infections

Recurrent respiratory infections

Recurrent bronchopulmonary infections

Recurrent lower respiratory tract infections

Disease(s) Associated with FAS

acute myeloid leukemia

autoimmune lymphoproliferative syndrome

chronic myeloid leukemia

cystic fibrosis

pre-eclampsia

rheumatoid arthritis

systemic lupus erythematosus

Mouse Phenotypes

immune system phenotype

lymph node hemorrhage

blood vessel inflammation

decreased B cell apoptosis

increased T cell apoptosis

decreased macrophage apoptosis

lymph node necrosis

impaired leukocyte tethering or rolling

abnormal leukocyte adhesion

abnormal T cell proliferation

submandibular gland inflammation

salivary gland inflammation

thymus cortex atrophy

abnormal thymus medulla morphology

increased thymus weight

enlarged thymus

thymus atrophy

abnormal thymus involution

thyroid gland inflammation

lacrimal gland inflammation

enlarged spleen

increased spleen weight

abnormal B cell receptor editing

decreased immature B cell number

decreased transitional stage B cell number

increased immature B cell number

increased transitional stage B cell number

abnormal T cell differentiation

abnormal T cell clonal deletion

increased double-negative T cell number

increased double-positive T cell number

decreased eosinophil cell number

increased neutrophil cell number

increased dendritic cell number

decreased mature B cell number

decreased marginal zone B cell number

increased follicular B cell number

increased marginal zone B cell number

increased plasma cell number

decreased B cell number

increased B cell number

increased NK cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased gamma-delta T cell number

increased memory T cell number

decreased T cell number

decreased activated T cell number

increased activated T cell number

increased lymphocyte cell number

increased leukocyte cell number

abnormal leukocyte morphology

abnormal B cell morphology

abnormal marginal zone B cell morphology

abnormal T cell morphology

abnormal spleen morphology

spleen hypoplasia

decreased spleen germinal center number

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal splenic cell ratio

increased splenocyte number

abnormal B cell activation

abnormal immunoglobulin level

increased IgA level

increased IgG1 level

increased IgG2a level

increased IgG2b level

increased IgG3 level

decreased IgG level

increased IgG level

increased IgM level

increased immunoglobulin level

abnormal NK cell physiology

abnormal T cell physiology

abnormal T-helper 2 physiology

abnormal cytotoxic T cell physiology

abnormal interleukin level

abnormal immune system morphology

abnormal immune system cell morphology

abnormal immune system organ morphology

enlarged Peyer's patches

abnormal lymph node morphology

abnormal lymph node cell ratio

enlarged lymph nodes

lymph node hyperplasia

lymph node hypoplasia

abnormal lymph organ size

lymphoid hyperplasia

abnormal immune system physiology

abnormal type III hypersensitivity reaction

increased susceptibility to type III hypersensitivity reaction

abnormal hypersensitivity reaction

decreased interleukin-2 secretion

autoimmune response

decreased susceptibility to autoimmune diabetes

decreased susceptibility to experimental autoimmune encephalomyelitis

increased susceptibility to autoimmune disorder

increased susceptibility to systemic lupus erythematosus

increased autoantibody level

increased anti-erythrocyte antigen antibody level

increased anti-nuclear antigen antibody level

increased anti-double stranded DNA antibody level

increased anti-histone antibody level

increased anti-single stranded DNA antibody level

increased inflammatory response

CNS inflammation

brain inflammation

conjunctivitis

liver inflammation

kidney inflammation

glomerulonephritis

lung inflammation

alveolitis

increased susceptibility to bacterial infection

increased susceptibility to parasitic infection

increased susceptibility to Picornaviridae infection

Availability

Mouse Genotype

Fas^lpr-cg/Fas^lpr-cg

Fas^lpr/Fas^lpr

Fas^m1Btlr/Fas^m1Btlr

Fas^m2Btlr/Fas^m2Btlr

Fas^theo/Fas^theo

Fas^tm1.1Cgn/Fas^tm1.1Cgn

Fas^tm1Cgn/Fas^tm1Cgn

Fas^tm1Dlo/Fas^tm1Dlo

Fas^tm1Osa/Fas^tm1Osa

Fas^lpr/Fas^tm1.1Cgn

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^tm1Ach/Fas^tm1Ach (conditional)

Fas^tm1Ach/Fas^tm1Ach
Tg(Lck-cre)548Jxm/? (conditional)

Fas^tm1Ach/Fas^tm1Ach
Tg(GZMB-cre)1Jcb/? (conditional)

Fas^tm1Ach/Fas^tm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/? (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Mog^tm1(cre)Gkl/Mog⁺ (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Tg(Lck-cre)I57Jxm/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^tm1Cgn/Fas^tm1Cgn (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Cd19^tm1(cre)Cgn/Cd19⁺
Tg(Cd4-cre)1Cwi/0 (conditional)

Fas^tm1Cgn/Fas^tm1Cgn
Tg(Mx1-cre)1Cgn/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^lpr/Fas^tm1Cgn (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Fas^lpr/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Fas^lpr/Fas^tm1Cgn
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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