Symbol
Name
ID

Cd28
CD28 antigen
MGI:88327

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Autoimmunity
Disease(s) Associated with CD28	Autoimmunity
type 1 diabetes mellitus

Mouse Phenotypes

increased T cell apoptosis

decreased T cell proliferation

increased T cell proliferation

increased splenocyte proliferation

enlarged thymus

enlarged spleen

abnormal lymphopoiesis

abnormal class switch recombination

increased B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased regulatory T cell number

decreased T cell number

increased activated T cell number

increased leukocyte cell number

decreased spleen germinal center number

abnormal germinal center B cell physiology

abnormal immunoglobulin level

decreased IgG1 level

decreased IgG2a level

increased IgG2a level

decreased IgG2b level

decreased IgM level

decreased immunoglobulin level

abnormal NK cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal cytotoxic T cell physiology

abnormal regulatory T cell physiology

decreased circulating interferon-gamma level

decreased circulating interleukin-4 level

enlarged lymph nodes

increased susceptibility to type I hypersensitivity reaction

decreased susceptibility to type IV hypersensitivity reaction

abnormal cytokine secretion

decreased interferon-gamma secretion

increased interferon-gamma secretion

decreased interleukin-12 secretion

decreased interleukin-2 secretion

decreased interleukin-4 secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

increased susceptibility to autoimmune disorder

increased susceptibility to autoimmune diabetes

increased susceptibility to experimental autoimmune encephalomyelitis

brain inflammation

skin inflammation

abnormal response to transplant

Availability

Mouse Genotype

Cd28^{tm1a(EUCOMM)Hmgu}/Cd28^{tm1a(EUCOMM)Hmgu}

Cd28^tm1Jmg/Cd28^tm1Jmg

Cd28^tm1Mak/Cd28^tm1Mak

Cd28^tm1Pjl/Cd28^tm1Pjl

Cd28^tm1Shr/Cd28^tm1Shr

Cd28^tm1Jmg/Cd28^tm1Mak

Cd28^tm1.1Huen/Cd28^tm1.1Huen
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ (conditional)

Cd28^tm1Ltu/Cd28^tm1Ltu
Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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