Symbol
Name
ID

Cd27
CD27 antigen
MGI:88326

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased lymphocyte proliferation in response to mitogen

Decreased circulating antibody level

Hemophagocytosis

Persistent EBV viremia

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Uveitis

Recurrent pneumonia

Sepsis

Recurrent infections

EBV meningitis

Severe varicella zoster infection

EBV encephalitis

Disease(s) Associated with CD27

lymphoproliferative syndrome 2

Mouse Phenotypes		immune system phenotype	increased T cell apoptosis	abnormal leukopoiesis	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	decreased regulatory T cell number	increased leukocyte cell number	abnormal spleen morphology	abnormal T cell physiology	abnormal CD4-positive, alpha-beta T cell physiology	abnormal cytotoxic T cell physiology
Availability	Mouse Genotype	immune system phenotype	increased T cell apoptosis	abnormal leukopoiesis		decreased regulatory T cell number	increased leukocyte cell number	abnormal spleen morphology	abnormal T cell physiology	abnormal CD4-positive, alpha-beta T cell physiology	abnormal cytotoxic T cell physiology
	Cd27^{em1(IMPC)Ccpcz}/Cd27^{em1(IMPC)Ccpcz}
	Cd27^tm1Jbo/Cd27^tm1Jbo	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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