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Symbol Name ID |
Bmi1
Bmi1 polycomb ring finger oncogene MGI:88174 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Acute myeloid leukemia |
Subacute progressive viral hepatitis |
| Disease(s) Associated with BMI1 | ||
| acute myeloid leukemia | ||
| hepatocellular carcinoma |
| Mouse Phenotypes | immune system phenotype |
decreased splenocyte proliferation |
abnormal thymus morphology |
thymus cortex hypoplasia |
small thymus |
thymus atrophy |
decreased thymocyte number |
abnormal thymus involution |
decreased immature B cell number |
abnormal double-negative T cell morphology |
decreased double-positive T cell number |
decreased mature B cell number |
decreased B cell number |
decreased T cell number |
decreased lymphocyte cell number |
abnormal spleen morphology |
abnormal spleen red pulp morphology |
decreased spleen red pulp amount |
decreased spleen weight |
small spleen |
abnormal spleen white pulp morphology |
absent spleen germinal center |
abnormal spleen periarteriolar lymphoid sheath morphology |
decreased spleen white pulp amount |
decreased IgM level |
abnormal immune system cell morphology |
abnormal immune system organ morphology |
lung inflammation |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||
| Bmi1tm1Brn/Bmi1tm1Brn | |||||||||||||||||||||||||||||
| Bmi1tm1Sgon/Bmi1tm1Sgon Commd10Tg(Vav1-icre)A2Kio/? (conditional) |
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| Bmi1tm1Sgon/Bmi1tm1Sgon Gt(ROSA)26Sortm1(cre/ERT2)Tyj/? (conditional) |
* | ||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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