Symbol
Name
ID

Aim2
absent in melanoma 2
MGI:2686159

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased macrophage apoptosis

abnormal thymus morphology

enlarged thymus

enlarged spleen

decreased NK cell number

abnormal spleen morphology

abnormal macrophage physiology

decreased circulating interleukin-18 level

abnormal cytokine secretion

abnormal interferon secretion

increased interferon-beta secretion

decreased interferon-gamma secretion

decreased interleukin-1 beta secretion

decreased interleukin-18 secretion

increased tumor necrosis factor secretion

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection

increased susceptibility to Poxviridae infection

Availability

Mouse Genotype

Aim2^{em1(IMPC)Ccpcz}/Aim2^{em1(IMPC)Ccpcz}

Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg}

Aim2^tm1.1Vmd/Aim2^tm1.1Vmd

Aim2^tm1Ktak/Aim2^tm1Ktak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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