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Symbol
Name
ID 		Asxl1
ASXL transcriptional regulator 1
MGI:2684063
Phenotype annotations related to immune system
Darker colors indicate more annotations
Human Phenotypes
Hemophagocytosis
Acute myeloid leukemia
Myeloproliferative disorder
Splenomegaly
Disease(s) Associated with ASXL1
acute myeloid leukemia
myelofibrosis

Mouse Phenotypes
abnormal thymus morphology
hepatosplenomegaly
enlarged spleen
spleen hyperplasia
abnormal lymphopoiesis
increased double-negative T cell number
abnormal myelopoiesis
myeloid hyperplasia
decreased neutrophil cell number
increased neutrophil cell number
abnormal neutrophil morphology
decreased mature B cell number
decreased B cell number
decreased pre-B cell number
decreased CD4-positive, alpha-beta T cell number
decreased T cell number
increased single-positive T cell number
decreased lymphocyte cell number
decreased monocyte cell number
increased monocyte cell number
decreased leukocyte cell number
increased leukocyte cell number
abnormal leukocyte morphology
abnormal spleen morphology
decreased spleen red pulp amount
decreased spleen weight
small spleen
spleen atrophy
abnormal spleen white pulp morphology
decreased splenocyte number
abnormal neutrophil physiology
abnormal immune system cell morphology
abnormal immune system organ morphology
Availability Mouse Genotype
Asxl1tm1.1Mjxu/Asxl1tm1.1Mjxu
Asxl1tm1Bc/Asxl1tm1Bc
Asxl1tm1.1Mjxu/Asxl1+
Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Tg(Vav1-Asxl1*Y588X)#Fcy/0
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tg(Mx1-cre)1Cgn/0  (conditional)
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tg(VAV1-cre)1Graf/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory