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Symbol
Name
ID 		Dicer1
dicer 1, ribonuclease type III
MGI:2177178
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Subacute progressive viral hepatitis
Disease(s) Associated with DICER1
hepatocellular carcinoma

Mouse Phenotypes
immune system phenotype
blood vessel inflammation
increased T cell apoptosis
abnormal granulocyte differentiation
decreased T cell proliferation
abnormal thymus morphology
abnormal thymus development
abnormal thymus epithelium morphology
abnormal thymus cortex morphology
abnormal thymus medulla morphology
athymia
decreased thymocyte number
abnormal thymus physiology
abnormal thymus involution
enlarged spleen
decreased immature B cell number
abnormal immunoglobulin V(D)J recombination
increased pro-B cell number
arrested B cell differentiation
abnormal positive T cell selection
decreased neutrophil cell number
abnormal neutrophil morphology
decreased germinal center B cell number
decreased mature B cell number
absent memory B cells
absent plasma cells
increased B-1 B cell number
decreased B cell number
decreased pre-B cell number
increased effector memory CD4-positive, alpha-beta T cell number
decreased CD4-positive, alpha-beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased gamma-delta T cell number
decreased regulatory T cell number
decreased T cell number
decreased single-positive T cell number
decreased leukocyte cell number
abnormal effector T cell morphology
abnormal regulatory T cell morphology
abnormal myeloid leukocyte morphology
abnormal splenic cell ratio
absent spleen
abnormal germinal center B cell physiology
decreased immunoglobulin level
abnormal CD4-positive, alpha-beta T cell physiology
abnormal T-helper 1 physiology
abnormal T-helper 2 physiology
abnormal cytotoxic T cell physiology
abnormal regulatory T cell physiology
abnormal lymph node cell ratio
enlarged lymph nodes
abnormal humoral immune response
increased susceptibility to induced arthritis
liver inflammation
lung inflammation
increased susceptibility to Herpesvirales infection
decreased susceptibility to Riboviria infection
increased susceptibility to Riboviria infection
Availability Mouse Genotype
Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Dicer1m1Btlr/Dicer1m1Btlr
Dicer1tm1b(EUCOMM)Wtsi/Dicer1+
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Cd4-cre)1Cwi/0  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Y  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Foxp3-EGFP/icre)1aJbs/0  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Dicer1tm1Bdh/Dicer1tm1Bdh
Aicdatm1(cre)Njen/Aicda+  (conditional)		 *
Dicer1tm1Dli/Dicer1tm1Dli
Tg(Cd4-cre)1Cwi/?  (conditional)		 *
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Lck-cre)1Cwi/0  (conditional)
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+  (conditional)
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)
Dicer1tm1Tara/Dicer1tm1Tara
Foxn1tm3(cre)Nrm/Foxn1+  (conditional)
Dicer1tm1Mmk/Dicer1tm1.1Mmk
Cd79atm1(cre)Reth/Cd79a+  (conditional)
Dicer1tm1Bdh/Dicer1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory