Symbol Name ID |
Lrba
LPS-responsive beige-like anchor MGI:1933162 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Decreased specific antibody response to vaccination |
Autoimmune hemolytic anemia |
Chronic neutropenia |
Decreased proportion of class-switched memory B cells |
B lymphocytopenia |
Autoimmune thrombocytopenia |
Recurrent sinusitis |
Conjunctivitis |
Lymphadenopathy |
Generalized lymphadenopathy |
Splenomegaly |
Inflammation of the large intestine |
Colitis |
Recurrent otitis media |
Thyroiditis |
Uveitis |
Erythema nodosum |
Pneumonia |
Recurrent pneumonia |
Immunodeficiency |
Asthma |
Sepsis |
Recurrent infections |
Recurrent respiratory infections |
Disease(s) Associated with LRBA | |||||||||||||||||||||||||||
common variable immunodeficiency 8 |
Mouse Phenotypes | increased susceptibility to induced colitis |
increased regulatory T cell number |
abnormal NK cell physiology |
impaired natural killer cell mediated cytotoxicity |
decreased susceptibility to graft versus host disease |
increased length of allograft survival |
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Availability | Mouse Genotype | ||||||
Lrbaem1Btlr/Lrbaem1Btlr | |||||||
Lrbaem2Btlr/Lrbaem2Btlr | |||||||
Lrbaem3Btlr/Lrbaem3Btlr | |||||||
LrbaGt(OST69142)Lex/LrbaGt(OST69142)Lex | |||||||
Lrbam1Btlr/Lrbam1Btlr | |||||||
Lrbam2Btlr/Lrbam2Btlr |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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