|
Symbol Name ID |
Tlr9
toll-like receptor 9 MGI:1932389 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukopenia |
Sinusitis |
Chronic sinusitis |
Pericarditis |
Lymphadenopathy |
Hepatosplenomegaly |
Subacute progressive viral hepatitis |
Pancreatitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Recurrent pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with TLR9 | |||||||||||||||||||||||||||||||||||
| allergic bronchopulmonary aspergillosis | |||||||||||||||||||||||||||||||||||
| asthma | |||||||||||||||||||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||||||||||||||||||
| hepatocellular carcinoma | |||||||||||||||||||||||||||||||||||
| IgA glomerulonephritis | |||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
abnormal leukocyte migration |
decreased B cell proliferation |
increased susceptibility to induced colitis |
abnormal B cell physiology |
abnormal NK cell physiology |
impaired natural killer cell mediated cytotoxicity |
abnormal T-helper 1 physiology |
abnormal NK T cell physiology |
abnormal macrophage physiology |
abnormal immune system physiology |
abnormal dendritic cell physiology |
abnormal plasmacytoid dendritic cell physiology |
abnormal cytokine secretion |
decreased interferon-alpha secretion |
decreased interferon-beta secretion |
decreased interferon-gamma secretion |
decreased interleukin-12b secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
decreased inflammatory response |
abnormal response to infection |
increased susceptibility to Herpesvirales infection induced morbidity/mortality |
decreased susceptibility to parasitic infection |
increased susceptibility to Herpesvirales infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||
| Tlr9M1Btlr/Tlr9M1Btlr | ||||||||||||||||||||||||||
| Tlr9M2Btlr/Tlr9M2Btlr | ||||||||||||||||||||||||||
| Tlr9m3Btlr/Tlr9m3Btlr | ||||||||||||||||||||||||||
| Tlr9m6Btlr/Tlr9m6Btlr | ||||||||||||||||||||||||||
| Tlr9M7Btlr/Tlr9M7Btlr | ||||||||||||||||||||||||||
| Tlr9M8Btlr/Tlr9M8Btlr | ||||||||||||||||||||||||||
| Tlr9M9Btlr/Tlr9M9Btlr | ||||||||||||||||||||||||||
| Tlr9tm1Aki/Tlr9tm1Aki | * | |||||||||||||||||||||||||
| Tlr9M2Btlr/Tlr9+ | ||||||||||||||||||||||||||
| Tlr9m4Btlr/Tlr9+ | ||||||||||||||||||||||||||
| Tlr9M5Btlr/Tlr9+ | ||||||||||||||||||||||||||
| Tlr9M7Btlr/Tlr9+ | ||||||||||||||||||||||||||
| Tlr9M9Btlr/Tlr9+ | ||||||||||||||||||||||||||
| Tlr9M5Btlr/? | ||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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