Symbol
Name
ID

Bcl11b
B cell leukemia/lymphoma 11B
MGI:1929913

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Eosinophilia	Decreased proportion of naive CD4 T cells	Abnormally low T cell receptor excision circle level	T lymphocytopenia	Lymphopenia	Impaired lymphocyte transformation with phytohemagglutinin	Psoriasiform dermatitis	Severe combined immunodeficiency
Disease(s) Associated with BCL11B
immunodeficiency 49

Mouse Phenotypes

immune system phenotype

increased thymocyte apoptosis

abnormal thymus cortex morphology

absent thymus corticomedullary boundary

abnormal thymus medulla morphology

thymus hypoplasia

decreased thymocyte number

abnormal thymocyte activation

increased spleen weight

spleen hyperplasia

abnormal NK cell differentiation

abnormal T cell differentiation

abnormal T cell receptor beta chain V(D)J recombination

abnormal positive T cell selection

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

increased dendritic cell number

increased B cell number

increased NK cell number

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased gamma-delta T cell number

absent T cells

abnormal leukocyte morphology

abnormal T cell morphology

enlarged mesenteric lymph nodes

Availability

Mouse Genotype

Bcl11b^tm1.2Leid/Bcl11b^tm1.2Leid

Bcl11b^tm1Jpk/Bcl11b^tm1Jpk

Bcl11b^tm1Avram/Bcl11b^tm1Avram
Tg(Cd4-cre)1Cwi/? (conditional)

Bcl11b^tm1Peli/Bcl11b^tm1Peli
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ (conditional)

Bcl11b^tm2.1Jpk/Bcl11b⁺
Tg(Cd4-cre)1Cwi/0 (conditional)

Bcl11b^tm2.1Jpk/Bcl11b⁺
Tg(Lck-cre)1Jtak/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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