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Symbol Name ID |
Sting1
stimulator of interferon response cGAMP interactor 1 MGI:1919762 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA concentration |
Increased circulating IgG concentration |
Decreased total lymphocyte count |
Decreased total leukocyte count |
Follicular hyperplasia |
Paratracheal lymphadenopathy |
Pustule |
Skin rash |
Malar rash |
Pustular rash |
Myositis |
Cytoplasmic antineutrophil antibody positivity |
Antinuclear antibody positivity |
Antiphospholipid antibody positivity |
Rheumatoid factor positive |
Recurrent infections |
Recurrent respiratory infections |
| Disease(s) Associated with STING1 | |||||||||||||||||
| STING-associated vasculopathy with onset in infancy |
| Mouse Phenotypes | immune system phenotype |
enlarged spleen |
decreased single-positive T cell number |
abnormal spleen morphology |
increased IgM level |
abnormal macrophage physiology |
abnormal MHC II cell surface expression on macrophages |
increased circulating CSF3 level |
increased circulating CCL2 level |
increased circulating CCL3 level |
decreased circulating interferon-alpha level |
decreased circulating interferon-beta level |
increased circulating interleukin-10 level |
increased circulating interleukin-13 level |
increased circulating interleukin-17 level |
decreased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
increased circulating cytokine level |
increased CCL4 level |
abnormal dendritic cell physiology |
abnormal plasmacytoid dendritic cell physiology |
abnormal level of surface class I molecules |
abnormal humoral immune response |
abnormal immune cell physiology |
abnormal interferon-beta secretion |
lung inflammation |
abnormal innate immunity |
abnormal response to infection |
increased susceptibility to Herpesvirales infection induced morbidity/mortality |
abnormal susceptibility to Herpesvirales infection |
increased susceptibility to Herpesvirales infection |
increased susceptibility to Retroviridae infection |
increased susceptibility to Riboviria infection |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||
| Sting1gt/Sting1gt | * | |||||||||||||||||||||||||||||||||
| Sting1tm1Camb/Sting1tm1Camb | * | |||||||||||||||||||||||||||||||||
| Sting1tm1Gnb/Sting1tm1Gnb | ||||||||||||||||||||||||||||||||||
| Sting1em1Jmin/Sting1+ | ||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/24/2026 MGI 6.24 |
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