Symbol
Name
ID

Foxp3
forkhead box P3
MGI:1891436

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgE level

Autoimmune hemolytic anemia

Eosinophilia

Neutropenia

Neutropenia in presence of anti-neutropil antibodies

Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells

Decreased FOXP3-expressing T cell count

Autoimmune thrombocytopenia

Lymphadenopathy

Splenomegaly

Colitis

Recurrent gastroenteritis

Hepatitis

Thyroiditis

Glomerulonephritis

Membranous nephropathy

Inflammatory abnormality of the skin

Crusting erythematous dermatitis

Eczematoid dermatitis

Erythroderma

Psoriasiform dermatitis

Recurrent skin infections

Myositis

Osteomyelitis

Pneumonia

Autoimmunity

Anti-glutamic acid decarboxylase antibody positivity

Anti-liver cytosolic antigen type 1 antibody positivity

Anti-thyroid peroxidase antibody positivity

Insulin receptor antibody positivity

Immune dysregulation

Allergy

Food allergy

Sepsis

Recurrent infections

Recurrent respiratory infections

Severe infection

Meningitis

Disease(s) Associated with FOXP3

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

increased T cell apoptosis

increased T cell proliferation

colitis

salivary gland inflammation

stomach inflammation

abnormal thymus morphology

abnormal thymus cortex morphology

small thymus

thymus hypoplasia

decreased thymocyte number

enlarged spleen

increased spleen weight

abnormal T cell differentiation

decreased double-positive T cell number

increased eosinophil cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

absent regulatory T cells

decreased T cell number

increased T cell number

increased activated T cell number

increased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

abnormal lymphocyte morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

abnormal effector T cell morphology

abnormal intraepithelial T cell morphology

abnormal regulatory T cell morphology

abnormal macrophage morphology

abnormal spleen morphology

increased spleen red pulp amount

intermingled spleen red and white pulp

abnormal spleen white pulp morphology

decreased spleen B cell follicle number

absent spleen marginal zone

increased spleen white pulp amount

abnormal lymphocyte physiology

abnormal B cell physiology

increased IgE level

increased IgG1 level

increased IgG level

increased IgM level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal regulatory T cell physiology

increased circulating interferon-gamma level

increased circulating interleukin-10 level

increased circulating interleukin-4 level

increased circulating interleukin-5 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal chemokine level

abnormal immune system organ morphology

abnormal gut-associated lymphoid tissue morphology

abnormal Peyer's patch morphology

abnormal lymph node morphology

abnormal mesenteric lymph node morphology

abnormal lymph node B cell domain morphology

abnormal lymph node T cell domain morphology

abnormal lymph node medullary cord morphology

enlarged lymph nodes

abnormal immune system physiology

increased susceptibility to type IV hypersensitivity reaction

lymph node inflammation

abnormal cytokine secretion

autoimmune response

increased susceptibility to autoimmune disorder

increased autoantibody level

abnormal inflammatory response

increased inflammatory response

blepharitis

conjunctivitis

liver inflammation

respiratory system inflammation

lung inflammation

skin inflammation

dermatitis

Availability

Mouse Genotype

Foxp3^sf/Foxp3^sf
Tg(Rorc-EGFP)1Ebe/?

Foxp3^{tm1(CD2/CD52)Shori}/Foxp3^{tm1(CD2/CD52)Shori}

Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr

Foxp3^tm2Ayr/Foxp3^tm2Ayr

Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr

Foxp3^tm6.2Ayr/Foxp3^tm6.2Ayr

Foxp3^tm7.2Ayr/Foxp3^tm7.2Ayr

Foxp3^tm2Tch/Foxp3⁺

Foxp3^tm3Tch/Foxp3⁺

Foxp3^tm7.2Ayr/Foxp3⁺

Foxp3^sf/Y

Foxp3^tm1(cre)Saka/Y

Foxp3^tm1.1Ayr/Y

Foxp3^tm1Tch/Y

Foxp3^{tm2.1(EGFP/cre)Shori}/Y

Foxp3^tm2Ayr/Y

Foxp3^tm2Flv/Y

Foxp3^tm2Tch/Y

Foxp3^tm3Tch/Y

Foxp3^tm8Ayr/Y

Foxp3^sf/?

Foxp3^tm1Ayr/Foxp3^tm1Ayr
Foxn1^tm3(cre)Nrm/Foxn1⁺ (conditional)

Foxp3^tm1Ayr/Foxp3^tm1Ayr
Tg(Cd4-cre)1Cwi/? (conditional)

Foxp3^tm1Ayr/Y
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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