Symbol
Name
ID

Rab27a
RAB27A, member RAS oncogene family
MGI:1861441

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Reduced delayed hypersensitivity	Neutropenia	Hemophagocytosis	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly	Immunodeficiency	Recurrent bacterial infections
Disease(s) Associated with RAB27A
Griscelli syndrome type 2

Mouse Phenotypes

immune system phenotype

abnormal NK cell degranulation

decreased NK cell degranulation

decreased neutrophil cell number

decreased leukocyte cell number

abnormal neutrophil physiology

impaired natural killer cell mediated cytotoxicity

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

increased circulating interferon-gamma level

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

increased susceptibility to Riboviria infection

Availability

Mouse Genotype

Rab27a^ash/Rab27a^ash

Rab27a^cct/Rab27a^cct

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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