Symbol Name ID |
Icos
inducible T cell co-stimulator MGI:1858745 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Secretory IgA deficiency |
Impaired T cell function |
Neutropenia in presence of anti-neutropil antibodies |
Decreased proportion of class-switched memory B cells |
B lymphocytopenia |
Abnormal T cell count |
Abnormal lymphocyte morphology |
Recurrent sinusitis |
Conjunctivitis |
Lymphadenopathy |
Splenomegaly |
Recurrent infection of the gastrointestinal tract |
Recurrent otitis media |
Chronic intestinal candidiasis |
Pneumonia |
Recurrent pneumonia |
Autoimmunity |
Immunodeficiency |
Recurrent infections |
Recurrent bacterial infections |
Recurrent respiratory infections |
Recurrent bronchitis |
Recurrent sinopulmonary infections |
Disease(s) Associated with ICOS | ||||||||||||||||||||||||||
common variable immunodeficiency 1 | ||||||||||||||||||||||||||
immunoglobulin alpha deficiency |
Mouse Phenotypes | immune system phenotype |
decreased T cell proliferation |
insulitis |
abnormal B cell selection |
abnormal class switch recombination |
abnormal T cell differentiation |
abnormal leukocyte cell number |
abnormal B cell number |
decreased germinal center B cell number |
decreased plasma cell number |
increased plasma cell number |
abnormal memory B cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased T cell number |
abnormal spleen morphology |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal B cell physiology |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG2c level |
increased IgG3 level |
decreased IgG level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 2 physiology |
decreased circulating interferon-gamma level |
decreased circulating interleukin-4 level |
abnormal interferon level |
abnormal interleukin level |
abnormal Peyer's patch germinal center morphology |
small Peyer's patches |
small lymph nodes |
abnormal immune system physiology |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
abnormal interleukin secretion |
decreased interleukin-21 secretion |
decreased interleukin-4 secretion |
decreased interleukin-5 secretion |
decreased susceptibility to autoimmune diabetes |
increased susceptibility to experimental autoimmune encephalomyelitis |
decreased autoantibody level |
decreased anti-insulin autoantibody level |
abnormal response to infection |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1.1Wks/Icostm1.1Wks | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1Dgry/Icostm1Dgry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1Flv/Icostm1Flv | * | |||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1Mak/Icostm1Mak | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1Shr/Icostm1Shr | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1Tkan/Icostm1Tkan | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Icostm1Flv/Icos+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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