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Symbol Name ID |
Rfx5
regulatory factor X, 5 (influences HLA class II expression) MGI:1858421 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Agammaglobulinemia |
Panhypogammaglobulinemia |
Cutaneous anergy |
Neutropenia |
Recurrent upper respiratory tract infections |
Colitis |
Viral hepatitis |
Cholangitis |
Recurrent urinary tract infections |
Chronic mucocutaneous candidiasis |
Recurrent bacterial infections |
Recurrent fungal infections |
Recurrent protozoan infections |
Recurrent lower respiratory tract infections |
Recurrent viral infections |
Infectious encephalitis |
Chronic lymphocytic meningitis |
| Disease(s) Associated with RFX5 | |||||||||||||||||
| MHC class II deficiency |
| Mouse Phenotypes | immune system phenotype |
abnormal Kupffer cell morphology |
abnormal thymus cortex morphology |
decreased CD4-positive, alpha-beta T cell number |
decreased single-positive T cell number |
abnormal dendritic cell morphology |
abnormal B lymphocyte antigen presentation |
decreased IgG1 level |
decreased IgM level |
abnormal MHC II cell surface expression on macrophages |
abnormal level of surface class II molecules |
|
| Availability | Mouse Genotype | |||||||||||
| Rfx5tm1.1Ifo/Rfx5tm1.1Ifo | ||||||||||||
| Rfx5tm1Ifo/Rfx5tm1Ifo | * | |||||||||||
| Rfx5tm1Ifo/Rfx5tm1.1Ifo Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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