Symbol
Name
ID

Nbn
nibrin
MGI:1351625

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Dysgammaglobulinemia

Autoimmune hemolytic anemia

B lymphocytopenia

T lymphocytopenia

Acute leukemia

Acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias

Sinusitis

Recurrent infection of the gastrointestinal tract

Recurrent otitis media

Recurrent urinary tract infections

Recurrent pneumonia

Recurrent respiratory infections

Recurrent bronchitis

Recurrent sinopulmonary infections

Disease(s) Associated with NBN

acute lymphoblastic leukemia

Nijmegen breakage syndrome

Mouse Phenotypes

immune system phenotype

decreased B cell proliferation

thymus hypoplasia

decreased thymocyte number

increased pro-B cell number

decreased mature B cell number

absent mature B cells

decreased B cell number

decreased pre-B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased leukocyte cell number

abnormal T cell morphology

abnormal B cell physiology

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

abnormal bone marrow development

abnormal cell-mediated immunity

Availability

Mouse Genotype

Nbn^tm1Jpt/Nbn^tm1Jpt

Nbn^tm1Xu/Nbn^tm1Xu

Nbn^tm2Zqw/Nbn^tm2Zqw
Tg(VAV1-cre)1Graf/0 (conditional)

Nbn^em7Jpt/Nbn^tm2Zqw
Tg(VAV1-cre)1Graf/0 (conditional)

Nbn^tm1Nus/Nbn^tm2Nus
Tg(CD19-cre/ERT2)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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