Symbol
Name
ID

Ikzf1
IKAROS family zinc finger 1
MGI:1342540

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating antibody level	B lymphocytopenia	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Combined immunodeficiency	Recurrent bacterial infections	Recurrent fungal infections	Recurrent viral infections
Disease(s) Associated with IKZF1	Decreased circulating antibody level	B lymphocytopenia	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Combined immunodeficiency	Recurrent bacterial infections	Recurrent fungal infections	Recurrent viral infections
acute lymphoblastic leukemia
common variable immunodeficiency 13

Mouse Phenotypes

immune system phenotype

abnormal B cell apoptosis

abnormal granulocyte differentiation

abnormal macrophage differentiation

decreased B cell proliferation

increased T cell proliferation

abnormal thymus morphology

abnormal thymus development

abnormal thymus lobule morphology

abnormal thymus cortex morphology

thymus cortex hypoplasia

abnormal thymus medulla morphology

enlarged thymus

thymus hypoplasia

decreased thymocyte number

decreased DN1 thymic pro-T cell number

decreased DN2 thymocyte number

decreased DN3 thymocyte number

abnormal thymocyte activation

enlarged spleen

spleen hyperplasia

abnormal lymphopoiesis

abnormal B cell differentiation

decreased immature B cell number

decreased pre-pro B cell number

absent pro-B cells

increased pro-B cell number

arrested B cell differentiation

abnormal T cell differentiation

decreased double-negative T cell number

decreased double-positive T cell number

arrested T cell differentiation

abnormal myelopoiesis

myeloid hyperplasia

increased basophil cell number

abnormal eosinophil morphology

decreased granulocyte number

abnormal dendritic cell number

decreased plasmacytoid dendritic cell number

abnormal B cell number

decreased mature B cell number

absent B-1a cells

decreased B-1a cell number

decreased B-1b cell number

increased B-1 B cell number

decreased B cell number

absent B cells

decreased pre-B cell number

absent pre-B cells

increased pre-B cell number

absent NK cells

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased mature gamma-delta T cell number

decreased gamma-delta intraepithelial T cell number

increased gamma-delta T cell number

decreased T cell number

absent T cells

decreased single-positive T cell number

increased T cell number

increased single-positive T cell number

increased macrophage cell number

abnormal NK cell morphology

abnormal spleen morphology

decreased spleen red pulp amount

intermingled spleen red and white pulp

decreased spleen germinal center number

increased spleen white pulp amount

abnormal splenic cell ratio

decreased splenocyte number

abnormal B cell physiology

abnormal B cell activation

decreased IgG3 level

increased IgG level

abnormal natural killer cell mediated cytotoxicity

abnormal immune system organ morphology

absent Peyer's patches

absent mesenteric lymph nodes

enlarged mesenteric lymph nodes

abnormal lymph node cortex morphology

abnormal lymph node medulla morphology

lymph node hyperplasia

abnormal peripheral lymph node morphology

absent axillary lymph nodes

absent cervical lymph nodes

enlarged cervical lymph nodes

absent inguinal lymph nodes

enhanced humoral immune response

lung inflammation

increased susceptibility to bacterial infection

increased response to antigen

Availability

Mouse Genotype

Ikzf1^m1Btlr/Ikzf1^m1Btlr

Ikzf1^m2Btlr/Ikzf1^m2Btlr

Ikzf1^m3Btlr/Ikzf1^m3Btlr

Ikzf1^plstc/Ikzf1^plstc

Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale

Ikzf1^tm1Kast/Ikzf1^tm1Kast

Ikzf1^tm1Kge/Ikzf1^tm1Kge

Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale

Ikzf1^tm2Kge/Ikzf1^tm2Kge

Ikzf1^plstc/Ikzf1⁺

Ikzf1^tm1Kge/Ikzf1⁺

Cd79a^tm1(cre)Reth/Cd79a⁺
Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu (conditional)

Ikzf1^tm3Kge/Ikzf1^tm3Kge
Tg(CD2-icre)4Kio/? (conditional)

Ikzf1^tm3Kge/Ikzf1^tm3Kge
Tg(CD19-cre/ERT2)1Cgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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