About   Help   FAQ
Symbol
Name
ID 		Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Leukocytosis
Recurrent pharyngitis
Conjunctivitis
Pericarditis
Lymphadenopathy
Cervical lymphadenopathy
Splenomegaly
Peritonitis
Uveitis
Nephritis
Abnormality of the immune system
Fasciitis
Erysipelas
Skin rash
Maculopapular exanthema
Myositis
Anti-citrullinated protein antibody positivity
Rheumatoid factor positive
Cellulitis
Disease(s) Associated with TNFRSF1A
allergic bronchopulmonary aspergillosis
autosomal dominant familial periodic fever
IgA glomerulonephritis
rheumatoid arthritis

Mouse Phenotypes
immune system phenotype
increased basophil cell number
increased eosinophil cell number
decreased neutrophil cell number
increased neutrophil cell number
increased NK cell number
increased effector memory CD8-positive, alpha-beta T cell number
increased lymphocyte cell number
increased large unstained cell number
decreased monocyte cell number
increased leukocyte cell number
decreased microglial cell number
abnormal spleen germinal center morphology
decreased IgG1 level
decreased IgG level
abnormal macrophage physiology
decreased circulating interleukin-1 beta level
decreased circulating interleukin-6 level
increased circulating tumor necrosis factor level
abnormal follicular dendritic cell morphology
absent follicular dendritic cells
abnormal Peyer's patch morphology
abnormal Peyer's patch follicle morphology
decreased Peyer's patch number
abnormal lymph node B cell domain morphology
abnormal immune system physiology
increased susceptibility to type I hypersensitivity reaction
impaired humoral immune response
abnormal cytokine secretion
abnormal chemokine secretion
decreased interleukin-6 secretion
increased interleukin-6 secretion
decreased susceptibility to autoimmune diabetes
decreased susceptibility to experimental autoimmune encephalomyelitis
increased susceptibility to experimental autoimmune encephalomyelitis
decreased susceptibility to endotoxin shock
increased susceptibility to endotoxin shock
granulomatous inflammation
decreased inflammatory response
liver inflammation
lung inflammation
decreased susceptibility to bacterial infection
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
increased susceptibility to parasitic infection
Availability Mouse Genotype
Tnfrsf1aem1(IMPC)Ccpcz/Tnfrsf1aem1(IMPC)Ccpcz
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnfrsf1atm1Rsie/Tnfrsf1atm1Rsie
Tnfrsf1atm2.1Rsie/Tnfrsf1atm2.1Rsie
Tnfrsf1atm2b(EUCOMM)Wtsi/Tnfrsf1atm2b(EUCOMM)Wtsi
Tnfrsf1atm1.1Gkl/Tnfrsf1a+
Tnfrsf1atm1Blt/Tnfrsf1a+
Tnfrsf1atm1Imx/Tnfrsf1a+
Tnfrsf1atm1Mak/Tnfrsf1a+
Tnfrsf1atm1Rsie/Tnfrsf1a+
Tnfrsf1atm2.1Rsie/Tnfrsf1a+ !
Tnfrsf1atm1Blt/Tnfrsf1atm2Gkl
Tg(Cr2-cre)3Cgn/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory