Symbol
Name
ID

Casp8
caspase 8
MGI:1261423

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Reduced CD95-induced lymphocyte apoptosis

Decreased circulating IgA level

Decreased circulating IgG level

Decreased circulating total IgM

Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine

Defective B cell activation

Decreased T cell activation

Decreased CD4:CD8 ratio

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Peritoneal abscess

Subacute progressive viral hepatitis

Eczematoid dermatitis

Pneumonia

Asthma

Recurrent sinopulmonary infections

Recurrent herpes

Disease(s) Associated with CASP8

autoimmune lymphoproliferative syndrome type 2B

hepatocellular carcinoma

pancreatic cancer

Mouse Phenotypes

decreased T cell apoptosis

abnormal macrophage differentiation

decreased B cell proliferation

abnormal T cell proliferation

decreased T cell proliferation

enlarged spleen

increased mast cell number

decreased B-1 B cell number

decreased marginal zone B cell number

decreased B cell number

increased B cell number

abnormal T cell subpopulation ratio

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

increased T cell number

increased lymphocyte cell number

decreased leukocyte cell number

abnormal lymphocyte morphology

abnormal T cell morphology

spleen hypoplasia

abnormal immunoglobulin level

increased IgE level

increased IgG1 level

abnormal T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal T cell activation

enlarged lymph nodes

lymphoid hyperplasia

abnormal adaptive immunity

liver inflammation

dermatitis

Availability

Mouse Genotype

Casp8^em1Hbz/Casp8^em1Hbz

Casp8^m1Btlr/Casp8^m1Btlr

Casp8^M2Btlr/Casp8^M2Btlr

Casp8^tm1Clie/Casp8^tm1Clie
Tg(Alb1-cre)7Gsc/0 (conditional)

Casp8^tm1Hed/Casp8^tm1Hed
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Casp8^tm1Hed/Casp8^tm1Hed
Tg(KRT14-cre)1Efu/0 (conditional)

Casp8^tm1Raz/Casp8^tm1Raz
Tg(Lck-cre)548Jxm/0 (conditional)

Casp8^tm1Wll/Casp8^tm1.1Yuan
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/28/2024 MGI 6.13