Symbol
Name
ID

Nfil3
nuclear factor, interleukin 3, regulated
MGI:109495

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

increased susceptibility to induced colitis

colitis

abnormal thymus morphology

small thymus

enlarged spleen

increased spleen weight

abnormal class switch recombination

abnormal NK cell differentiation

decreased dendritic cell number

decreased NK cell number

increased T-helper 17 cell number

increased NK T cell number

increased memory T cell number

abnormal leukocyte morphology

abnormal plasma cell morphology

abnormal spleen morphology

decreased IgE level

decreased IgG1 level

impaired natural killer cell mediated cytotoxicity

increased macrophage cytokine production

abnormal circulating cytokine level

increased circulating interferon-gamma level

increased circulating interleukin-10 level

increased circulating interleukin-12b level

increased circulating interleukin-17 level

increased circulating tumor necrosis factor level

abnormal cytokine secretion

decreased interferon-gamma secretion

increased interferon-gamma secretion

abnormal interleukin secretion

decreased interleukin-10 secretion

increased interleukin-10 secretion

increased interleukin-12b secretion

decreased interleukin-13 secretion

increased interleukin-13 secretion

decreased interleukin-17 secretion

increased interleukin-17 secretion

increased interleukin-3 secretion

decreased interleukin-4 secretion

decreased interleukin-9 secretion

increased tumor necrosis factor secretion

increased susceptibility to experimental autoimmune encephalomyelitis

Availability

Mouse Genotype

Nfil3^{tm1.1(KOMP)Vlcg}/Nfil3^{tm1.1(KOMP)Vlcg}

Nfil3^tm1.1Brad/Nfil3^tm1.1Brad

Nfil3^tm1.1Kubo/Nfil3^tm1.1Kubo

Nfil3^tm1Look/Nfil3^tm1Look

Nfil3^tm1Pbro/Nfil3^tm1Pbro

Nfil3^tm1.1Brad/Nfil3⁺

Tg(Igh-Nfil3)#Kubo/0

Commd10^{Tg(Vav1-icre)A2Kio}/0
Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo (conditional)

Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo
Tg(Itgax-cre)1-1Reiz/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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