Symbol Name ID |
Nfe2l2
nuclear factor, erythroid derived 2, like 2 MGI:108420 |
Darker colors indicate more annotations |
Human Phenotypes | Subacute progressive viral hepatitis |
Disease(s) Associated with NFE2L2 | |
hepatocellular carcinoma |
Mouse Phenotypes | increased splenocyte apoptosis |
abnormal leukocyte adhesion |
increased susceptibility to induced colitis |
abnormal thymus morphology |
enlarged thymus |
enlarged spleen |
increased spleen weight |
decreased CD4-positive, alpha-beta T cell number |
decreased T cell number |
increased macrophage cell number |
abnormal neutrophil physiology |
increased IgG level |
increased IgM level |
abnormal macrophage physiology |
abnormal splenocyte physiology |
decreased circulating interleukin-1 beta level |
increased circulating interleukin-1 beta level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal lymph node morphology |
enlarged lymph nodes |
abnormal spleen physiology |
decreased interleukin-1 beta secretion |
decreased tumor necrosis factor secretion |
increased susceptibility to experimental autoimmune uveoretinitis |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
increased acute inflammation |
liver inflammation |
glomerulonephritis |
lung inflammation |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
Nfe2l2em1(IMPC)Ccpcz/Nfe2l2em1(IMPC)Ccpcz | ||||||||||||||||||||||||||||||||
Nfe2l2tm1Mym/Nfe2l2tm1Mym | ||||||||||||||||||||||||||||||||
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk | ||||||||||||||||||||||||||||||||
Nfe2l2tm1.1Sred/Nfe2l2tm1.1Sred Tg(Scgb1a1-cre)1Grau/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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