Symbol Name ID |
Inpp5d
inositol polyphosphate-5-phosphatase D MGI:107357 |
Darker colors indicate more annotations |
Mouse Phenotypes | abnormal granulocyte differentiation |
abnormal mononuclear cell differentiation |
abnormal monocyte differentiation |
abnormal osteoclast differentiation |
abnormal macrophage chemotaxis |
increased mast cell degranulation |
intestinal inflammation |
ileum inflammation |
enlarged thymus |
small thymus |
decreased thymocyte number |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal lymphopoiesis |
abnormal B cell differentiation |
decreased pro-B cell number |
abnormal T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal myelopoiesis |
increased neutrophil cell number |
increased dendritic cell number |
abnormal lymphocyte cell number |
absent marginal zone B cells |
increased B-1 B cell number |
decreased B cell number |
decreased pre-B cell number |
decreased NK cell number |
increased NK cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased alpha-beta T cell number |
decreased lymphocyte cell number |
increased macrophage cell number |
increased osteoclast cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal lymphocyte morphology |
abnormal NK cell morphology |
abnormal osteoclast morphology |
abnormal spleen marginal zone macrophage morphology |
abnormal myeloid leukocyte morphology |
abnormal leukocyte physiology |
abnormal eosinophil physiology |
abnormal neutrophil physiology |
abnormal B cell physiology |
increased IgG2a level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
impaired natural killer cell mediated cytotoxicity |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal cytotoxic T cell physiology |
decreased cytotoxic T cell cytolysis |
abnormal osteoclast physiology |
increased circulating interleukin-6 level |
abnormal interferon level |
abnormal interleukin level |
abnormal lymph node germinal center morphology |
enlarged lymph nodes |
abnormal cell-mediated immunity |
abnormal humoral immune response |
increased interferon-beta secretion |
abnormal interleukin secretion |
increased tumor necrosis factor secretion |
increased susceptibility to systemic lupus erythematosus |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-chromatin antibody level |
increased anti-double stranded DNA antibody level |
increased anti-single stranded DNA antibody level |
lung inflammation |
decreased susceptibility to parasitic infection |
decreased susceptibility to graft versus host disease |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5del20/Inpp5del20 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dm1Anu/Inpp5dm1Anu | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dm1Btlr/Inpp5dm1Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dm2Btlr/Inpp5dm2Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dm4Btlr/Inpp5dm4Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dm5Btlr/Inpp5dm5Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dtm1.1Wgk/Inpp5dtm1.1Wgk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dtm1Dmt/Inpp5dtm1Dmt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dtm1Rkh/Inpp5dtm1Rkh | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dM3Btlr/Inpp5d+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inpp5dtm1Rav/Inpp5dtm1Rav Tg(Cd4-cre)1Cwi/? (conditional) |
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Cd79atm1(cre)Reth/Cd79a+ Inpp5dtm1Rav/Inpp5dtm1Rav (conditional) |
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Inpp5dtm1Wgk/Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn/0 (conditional) |
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Inpp5dtm1Rav/Inpp5dtm1.1Rav Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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