Symbol Name ID |
Cxcr2
C-X-C motif chemokine receptor 2 MGI:105303 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Nephritis |
Disease(s) Associated with CXCR2 | |
IgA glomerulonephritis |
Mouse Phenotypes | immune system phenotype |
abnormal granulocyte differentiation |
impaired neutrophil chemotaxis |
decreased thymus weight |
enlarged spleen |
increased spleen weight |
decreased immature B cell number |
decreased pre-pro B cell number |
abnormal myelopoiesis |
myeloid hyperplasia |
increased eosinophil cell number |
increased neutrophil cell number |
increased granulocyte number |
increased CD103-positive CD11b-low dendritic cell number |
decreased mature B cell number |
decreased B cell number |
decreased pre-B cell number |
increased B cell number |
increased memory-marker NK cell number |
increased CD4-positive, alpha-beta memory T cell number |
increased KLRG1+ CD4 alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta memory T cell number |
increased KLRG1+ CD8 alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased memory-marker CD4-positive NK T cell number |
increased effector memory T-helper cell number |
increased memory-marker gamma-delta T cell number |
increased gamma-delta T cell number |
decreased T cell number |
increased Ly6C high monocyte number |
increased Ly6C low monocyte number |
increased monocyte cell number |
increased leukocyte cell number |
decreased spleen weight |
abnormal spleen white pulp morphology |
abnormal leukocyte physiology |
abnormal eosinophil physiology |
abnormal neutrophil physiology |
impaired neutrophil recruitment |
increased IgE level |
abnormal T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 2 physiology |
abnormal NK T cell physiology |
increased circulating interleukin-6 level |
abnormal chemokine level |
abnormal interleukin level |
lymph node medullary cord hyperplasia |
enlarged lymph nodes |
enlarged cervical lymph nodes |
abnormal cytokine secretion |
decreased susceptibility to induced arthritis |
increased anti-nuclear antigen antibody level |
decreased susceptibility to bacterial infection induced morbidity/mortality |
increased susceptibility to bacterial infection |
decreased susceptibility to fungal infection |
increased susceptibility to parasitic infection |
increased susceptibility to Herpesvirales infection |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cxcr2tm1a(EUCOMM)Wtsi/Cxcr2tm1a(EUCOMM)Wtsi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cxcr2tm1Mwm/Cxcr2tm1Mwm | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cxcr2tm1Mwm/Cxcr2+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cxcr2tm1Rmra/Cxcr2tm1Rmra Tg(Mx1-cre)1Cgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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