|
Symbol Name ID |
Pdcd1
programmed cell death 1 MGI:104879 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA concentration |
Abnormal circulating IgE concentration |
Increased circulating IgG concentration |
Abnormal circulating IgM concentration |
Decreased total leukocyte count |
Pericarditis |
Lymphadenopathy |
Splenomegaly |
Peritoneal abscess |
Subacute progressive viral hepatitis |
Recurrent otitis media |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Anti-complement component C1q antibody positivity |
Anti-glutamic acid decarboxylase antibody positivity |
Anti-insulin antibody positivity |
Anti-islet antigen-2 antibody positivity |
Anti-phosphatidic acid antibody positivity |
Anti-ribosome Po antibody positivity |
Anti-Ro52/TRIM21 antibody positivity |
Anti-titin antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-nucleoporin 62 antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Immune dysregulation |
Extrapulmonary tuberculosis |
Pneumocystis jirovecii pneumonia |
| Disease(s) Associated with PDCD1 | ||||||||||||||||||||||||||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||||||||||||||||||||||||||
| infantile onset multisystem autoimmune disease 4 | ||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | increased B cell proliferation |
enlarged spleen |
abnormal leukopoiesis |
abnormal myelopoiesis |
decreased B-1 B cell number |
increased B-1 B cell number |
increased B cell number |
increased T-helper 1 cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased regulatory T cell number |
increased regulatory T cell number |
increased lymphocyte cell number |
abnormal immunoglobulin level |
increased IgA level |
increased IgG2b level |
increased IgG3 level |
increased IgM level |
abnormal T cell activation |
abnormal cytokine secretion |
increased interferon-gamma secretion |
increased susceptibility to experimental autoimmune encephalomyelitis |
increased autoantibody level |
increased inflammatory response |
autoimmune arthritis |
glomerulonephritis |
abnormal response to transplant |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Pdcd1tm1.1Liux/Pdcd1tm1.1Liux | |||||||||||||||||||||||||||
| Pdcd1tm1.1Shr/Pdcd1tm1.1Shr | |||||||||||||||||||||||||||
| Pdcd1tm1Hon/Pdcd1tm1Hon | |||||||||||||||||||||||||||
| Pdcd1tm1Llc/Pdcd1tm1Llc | |||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/24/2026 MGI 6.24 |
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