|
Symbol Name ID |
Stat3
signal transducer and activator of transcription 3 MGI:103038 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgE level |
Eosinophilia |
Recurrent upper respiratory tract infections |
Eosinophilic infiltration of the esophagus |
Chronic otitis media |
Iridocyclitis |
Epididymitis |
Cutaneous abscess |
Recurrent cutaneous abscess formation |
Eczematoid dermatitis |
Erythema nodosum |
Chronic mucocutaneous candidiasis |
Chronic oral candidiasis |
Skin rash |
Osteomyelitis |
Recurrent pneumonia |
Anti-citrullinated protein antibody positivity |
Rheumatoid factor positive |
Candida esophagitis |
Recurrent infections |
Recurrent Staphylococcus aureus infections |
Recurrent fungal infections |
Recurrent respiratory infections |
Recurrent sinopulmonary infections |
Cellulitis |
| Disease(s) Associated with STAT3 | |||||||||||||||||||||||||
| Behcet's disease | |||||||||||||||||||||||||
| hyper IgE recurrent infection syndrome 1 | |||||||||||||||||||||||||
| rheumatoid arthritis |
| Mouse Phenotypes | increased thymocyte apoptosis |
increased T cell apoptosis |
decreased T cell proliferation |
intestinal inflammation |
cecum inflammation |
colitis |
ileum inflammation |
decreased thymocyte number |
lacrimal gland inflammation |
abnormal CD4-positive T cell differentiation |
abnormal T-helper 17 cell differentiation |
increased neutrophil cell number |
increased granulocyte number |
increased dendritic cell number |
increased T-helper 1 cell number |
decreased T-helper 17 cell number |
increased T-helper 17 cell number |
increased CD4-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased T cell number |
increased macrophage cell number |
increased monocyte cell number |
increased leukocyte cell number |
increased IgE level |
decreased IgG1 level |
decreased IgG3 level |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal macrophage physiology |
increased circulating interferon-gamma level |
increased circulating interleukin-17 level |
increased circulating tumor necrosis factor level |
abnormal cytokine level |
abnormal interleukin level |
abnormal gut-associated lymphoid tissue morphology |
abnormal cytokine secretion |
increased interferon-gamma secretion |
increased interleukin-12 secretion |
decreased interleukin-17 secretion |
increased interleukin-17 secretion |
increased interleukin-6 secretion |
increased tumor necrosis factor secretion |
abnormal inflammatory response |
abnormal acute inflammation |
increased susceptibility to endotoxin shock |
granulomatous inflammation |
increased inflammatory response |
conjunctivitis |
liver inflammation |
lung inflammation |
dermatitis |
abnormal innate immunity |
abnormal response to infection |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat3tm1Desi/Stat3tm1Desi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat3tm3Vpo/Stat3tm3Vpo | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat3tm1Dnl/Stat3tm1Dlv | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(Stat3*)9199Alau/0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv Tg(Cd4-cre)1Cwi/0 (conditional) |
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| Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv (conditional) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat3tm1Aki/Stat3tm1Aki Tg(Tek-cre)12Flv/0 (conditional) |
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| Stat3tm1Dlv/Stat3tm1Dlv Tg(Cd4-cre)1Cwi/? (conditional) |
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| Stat3tm1Dlv/Stat3tm1Dlv Tg(Csf1r-icre)1Jwp/0 (conditional) |
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| Stat3tm1Dlv/Stat3tm1Dlv Tg(MMTV-cre)4Mam/0 (conditional) |
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| Stat3tm1Flv/Stat3tm1Flv Tg(Tek-cre)1Xyfu/0 (conditional) |
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| Stat3tm1Flv/Stat3tm1Flv Tg(Tek-cre)12Flv/0 (conditional) |
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| Stat3tm1Vpo/Stat3tm1Vpo Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Stat3tm2Aki/Stat3tm2Aki (conditional) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stat3tm2Aki/Stat3tm2Aki Tg(Lck-cre)1Jtak/0 (conditional) |
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| Stat3tm2Aki/Stat3tm2Aki Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Stat3tm2Aki/Stat3tm2Aki Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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| Stat3tm2Aki/Stat3tm2Aki Tg(KRT5-cre)1Tak/0 (conditional) |
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| Stat3tm1Vpo/Stat3tm2Vpo Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Stat3tm1Xyfu/Stat3+ Tg(Myh6-cre)2182Mds/0 (conditional) |
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| Stat3tm1Xyfu/Stat3tm1.1Xyfu Tg(Ttr-cre)10-3Xyfu/? (conditional) |
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| Stat3tm1Xyfu/Stat3tm1.1Xyfu Tg(Myh6-cre)2182Mds/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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