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Symbol
Name
ID

Tpp2
tripeptidyl peptidase II
MGI:102724

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

increased T cell apoptosis

thymus atrophy

enlarged spleen

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

increased B cell number

decreased CD8-positive, alpha-beta T cell number

increased memory T cell number

decreased T cell number

increased T cell number

increased single-positive T cell number

decreased leukocyte cell number

abnormal spleen morphology

increased spleen red pulp amount

abnormal splenic cell ratio

abnormal lymphocyte physiology

abnormal cytotoxic T cell physiology

abnormal immune system cell morphology

abnormal immune system organ morphology

enlarged lymph nodes

abnormal antigen presentation

abnormal level of surface class I molecules

increased autoantibody level

increased anti-nuclear antigen antibody level

Availability

Mouse Genotype

Tpp2^{Gt(OST432061)Lex}/Tpp2^{Gt(OST432061)Lex}

Tpp2^tm1.1Gnie/Tpp2^tm1.1Gnie

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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