Symbol
Name
ID

Cav1
caveolin 1, caveolae protein
MGI:102709

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with CAV1	Splenomegaly	Hepatosplenomegaly
congenital generalized lipodystrophy type 3

Mouse Phenotypes

abnormal osteoclast morphology

abnormal neutrophil physiology

impaired neutrophil recruitment

abnormal macrophage physiology

increased circulating CXCL10 level

increased circulating interferon-gamma level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal cytokine level

abnormal chemokine secretion

decreased susceptibility to endotoxin shock

lung inflammation

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Cav1^tm1Mls/Cav1^tm1Mls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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