|
Symbol Name ID |
Mc4r
melanocortin 4 receptor MGI:99457 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased resting energy expenditure |
| Disease(s) Associated with MC4R | |
| obesity |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
increased susceptibility to diet-induced obesity |
increased hydroxyproline level |
hyperglycemia |
increased circulating insulin level |
increased circulating leptin level |
increased circulating cholesterol level |
increased circulating free fatty acids level |
increased circulating interleukin-6 level |
increased circulating alanine transaminase level |
increased circulating aspartate transaminase level |
increased energy expenditure |
abnormal oxygen consumption |
decreased oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
decreased circulating adiponectin level |
increased liver triglyceride level |
|
| Availability | Mouse Genotype | ||||||||||||||||||
| Mc4rtm1.1Fbz/Mc4rtm1.1Fbz | |||||||||||||||||||
| Mc4rtm1Dhu/Mc4rtm1Dhu | |||||||||||||||||||
| Mc4rtm1Lowl/Mc4rtm1Lowl | |||||||||||||||||||
| Mc4rtm1Matsu/Mc4rtm1Matsu | |||||||||||||||||||
| Mc4rGlu3/Mc4r+ | |||||||||||||||||||
| Mc4rtm1.1Fbz/Mc4r+ | * | ||||||||||||||||||
| Mc4rtm1Lowl/Mc4rtm1Lowl Tg(Sim1-cre)1Lowl/0 (conditional) |
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| Mc4rtm1Lowl/Mc4rtm1Lowl Chattm1(cre)Lowl/Chat+ (conditional) |
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| Mc4rtm1Lowl/Mc4rtm1Lowl Slc17a6tm2(cre)Lowl/Slc17a6+ (conditional) |
* | ||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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