Symbol Name ID |
Pomc
pro-opiomelanocortin-alpha MGI:97742 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Pedal edema |
Elevated circulating C-reactive protein concentration |
Elevated circulating amyloid A concentration |
Elevated erythrocyte sedimentation rate |
Decreased resting energy expenditure |
Pleural effusion |
Fever |
Recurrent fever |
Proteinuria |
Amyloidosis |
Renal amyloidosis |
Ascites |
Disease(s) Associated with POMC | ||||||||||||
familial Mediterranean fever | ||||||||||||
obesity |
Mouse Phenotypes | homeostasis/metabolism phenotype |
increased susceptibility to diet-induced obesity |
increased circulating glucose level |
decreased circulating adrenaline level |
decreased circulating corticosterone level |
increased circulating corticosterone level |
increased circulating insulin level |
increased circulating leptin level |
decreased circulating aldosterone level |
decreased circulating adrenocorticotropin level |
increased circulating adrenocorticotropin level |
decreased circulating thyroxine level |
increased circulating interleukin-6 level |
increased urine adrenaline level |
increased dopamine level |
decreased oxygen consumption |
impaired glucose tolerance |
insulin resistance |
abnormal corticosterone level |
decreased adrenocorticotropin level |
abnormal response/metabolism to endogenous compounds |
increased physiological sensitivity to xenobiotic |
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Availability | Mouse Genotype | ||||||||||||||||||||||
Pomctm1.1Kgm/Pomctm1.1Kgm | * | ||||||||||||||||||||||
Pomctm1Low/Pomctm1Low | * | ||||||||||||||||||||||
Pomctm1Low/Pomctm1Low Tg(Pomc)#Low/0 |
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Pomctm1Low/Pomctm1Low Tg(Pomc)#Low/Tg(Pomc)#Low |
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Pomctm1Sora/Pomctm1Sora | |||||||||||||||||||||||
Pomctm2Low/Pomctm2Low | |||||||||||||||||||||||
Pomctm2Ute/Pomctm2Ute | |||||||||||||||||||||||
Pomcem1(IMPC)Rbrc/Pomc+ | |||||||||||||||||||||||
Pomctm1Sora/Pomc+ | |||||||||||||||||||||||
Pomctm2Ute/Pomc+ | |||||||||||||||||||||||
Tg(Pomc)#Low/0 | * | ||||||||||||||||||||||
Pomctm2Low/Pomctm2Low Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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