Symbol Name ID |
Abcb4
ATP-binding cassette, sub-family B member 4 MGI:97569 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA level |
Increased circulating IgM level |
Conjugated hyperbilirubinemia |
Increased serum bile acid concentration |
Increased serum bile acid concentration during pregnancy |
Abnormal circulating lipid concentration |
Hypercholesterolemia |
Hypoalbuminemia |
Elevated circulating hepatic transaminase concentration |
Abnormal liver function tests during pregnancy |
Elevated gamma-glutamyltransferase level |
Elevated circulating alkaline phosphatase concentration |
Ascites |
Disease(s) Associated with ABCB4 | |||||||||||||
intrahepatic cholestasis of pregnancy 3 | |||||||||||||
primary biliary cholangitis | |||||||||||||
progressive familial intrahepatic cholestasis 3 |
Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased intestinal cholesterol absorption |
increased circulating creatinine level |
abnormal blood homeostasis |
abnormal circulating bilirubin level |
increased circulating bilirubin level |
decreased circulating glucose level |
decreased circulating HDL cholesterol level |
decreased circulating cholesterol level |
decreased circulating calcium level |
increased circulating phosphate level |
increased circulating potassium level |
abnormal circulating enzyme level |
abnormal circulating alanine transaminase level |
increased circulating alanine transaminase level |
abnormal circulating alkaline phosphatase level |
increased circulating alkaline phosphatase level |
increased circulating amylase level |
abnormal circulating aspartate transaminase level |
increased circulating aspartate transaminase level |
abnormal sodium ion homeostasis |
abnormal lipid homeostasis |
increased bile salt level |
decreased vitamin D level |
increased transforming growth factor beta level |
increased tumor necrosis factor (ligand) superfamily member 11 level |
abnormal enzyme/coenzyme activity |
increased alkaline phosphatase activity |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||
Abcb4em1(IMPC)H/Abcb4em1(IMPC)H | |||||||||||||||||||||||||||||
Abcb4tm1Bor/Abcb4tm1Bor | * | ! | ! |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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