Symbol Name ID |
Pcsk1
proprotein convertase subtilisin/kexin type 1 MGI:97511 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Decreased resting energy expenditure |
Hypoglycemic seizures |
Reactive hypoglycemia |
Hyperinsulinemia |
Hypoinsulinemia |
Decreased circulating cortisol level |
Elevated circulating proinsulin concentration |
Disease(s) Associated with PCSK1 | |||||||
obesity | |||||||
proprotein convertase 1/3 deficiency |
Mouse Phenotypes | homeostasis/metabolism phenotype |
increased susceptibility to diet-induced obesity |
decreased circulating glucose level |
hypoglycemia |
decreased circulating glucagon level |
decreased circulating insulin level |
increased circulating insulin level |
increased circulating leptin level |
decreased circulating growth hormone level |
increased circulating interferon-gamma level |
increased circulating interleukin-1 beta level |
increased circulating interleukin-10 level |
increased circulating interleukin-12 level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal glucose tolerance |
impaired glucose tolerance |
insulin resistance |
abnormal hormone level |
decreased adrenocorticotropin level |
abnormal metabolism |
increased susceptibility to xenobiotic induced morbidity/mortality |
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Availability | Mouse Genotype | ||||||||||||||||||||||
Pcsk1em2Irli/Pcsk1em2Irli | |||||||||||||||||||||||
Pcsk1mpc242H/Pcsk1mpc242H | |||||||||||||||||||||||
Pcsk1N222D/Pcsk1N222D | |||||||||||||||||||||||
Pcsk1tm1Dfs/Pcsk1tm1Dfs | |||||||||||||||||||||||
Pcsk1tm1Dfs/Pcsk1+ | |||||||||||||||||||||||
Pcsk1tm1Mbi/Pcsk1+ | * |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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