|
Symbol Name ID |
Il10
interleukin 10 MGI:96537 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Increased circulating IgG level |
Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Decreased circulating antibody level |
Paraproteinemia |
Periorbital edema |
Pedal edema |
Abnormality of metabolism/homeostasis |
Hypercalcemia |
Hyperbilirubinemia |
Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypertriglyceridemia |
Elevated circulating creatinine concentration |
Elevated circulating C-reactive protein concentration |
Hyperproteinemia |
Elevated circulating hepatic transaminase concentration |
Elevated circulating alkaline phosphatase concentration |
Reduced leukocyte alkaline phosphatase |
Elevated erythrocyte sedimentation rate |
Glucose intolerance |
Diabetes mellitus |
Type II diabetes mellitus |
Impaired glucose tolerance |
Insulin resistance |
Joint swelling |
Pleural effusion |
Fever |
Abnormality of vitamin B12 metabolism |
Hematuria |
Pyuria |
Decreased level of D-mannose in urine |
Increased level of L-fucose in urine |
Proteinuria |
Amyloidosis |
Increased circulating free T3 |
Increased circulating free T4 concentration |
Decreased thyroid-stimulating hormone level |
| Disease(s) Associated with IL10 | ||||||||||||||||||||||||||||||||||||||||
| Behcet's disease | ||||||||||||||||||||||||||||||||||||||||
| chronic myeloid leukemia | ||||||||||||||||||||||||||||||||||||||||
| coronary artery disease | ||||||||||||||||||||||||||||||||||||||||
| factor VIII deficiency | ||||||||||||||||||||||||||||||||||||||||
| graft-versus-host disease | ||||||||||||||||||||||||||||||||||||||||
| granulomatosis with polyangiitis | ||||||||||||||||||||||||||||||||||||||||
| Graves' disease | ||||||||||||||||||||||||||||||||||||||||
| lymphoplasmacytic lymphoma | ||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer | ||||||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis | ||||||||||||||||||||||||||||||||||||||||
| Sjogren's syndrome | ||||||||||||||||||||||||||||||||||||||||
| stomach cancer | ||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | ||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia | ||||||||||||||||||||||||||||||||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | impaired exercise endurance |
increased myocardial infarct size |
increased susceptibility to neuronal excitotoxicity |
decreased spleen iron level |
abnormal homeostasis |
impaired adaptive thermogenesis |
decreased circulating creatinine level |
decreased circulating insulin level |
decreased circulating cholesterol level |
increased circulating cholesterol level |
decreased circulating iron level |
abnormal circulating protein level |
increased circulating interferon-gamma level |
increased circulating interleukin-1 alpha level |
increased circulating interleukin-1 beta level |
decreased circulating interleukin-10 level |
increased circulating interleukin-12 level |
abnormal circulating interleukin-12b level |
increased circulating interleukin-17 level |
increased circulating interleukin-2 level |
abnormal circulating interleukin-6 level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal circulating enzyme level |
abnormal circulating serum albumin level |
abnormal nitric oxide homeostasis |
abnormal glucose homeostasis |
increased insulin sensitivity |
abnormal iron level |
abnormal lipid level |
increased fatty acids level |
increased leukotriene level |
increased liver triglyceride level |
abnormal protein level |
abnormal cytokine level |
abnormal chemokine level |
abnormal interferon level |
abnormal interleukin level |
abnormal tumor necrosis factor level |
decreased physiological sensitivity to xenobiotic |
increased cerebral infarct size |
enhanced wound healing |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||
| Il10tm1.1Roer/Il10tm1.1Roer | |||||||||||||||||||||||||||||||||||||||||||
| Il10tm1Cgn/Il10tm1Cgn | |||||||||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Il10tm1Roer/Il10tm1Roer (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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