Symbol
Name
ID

Akt1
thymoma viral proto-oncogene 1
MGI:87986

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Elevated circulating hepatic transaminase concentration	Reduced leukocyte alkaline phosphatase	Diabetes mellitus	Fever
Disease(s) Associated with AKT1	Elevated circulating hepatic transaminase concentration	Reduced leukocyte alkaline phosphatase	Diabetes mellitus	Fever
chronic myeloid leukemia
pancreatic cancer

Mouse Phenotypes

homeostasis/metabolism phenotype

increased fatty acid oxidation

decreased susceptibility to diet-induced obesity

decreased circulating leptin level

decreased circulating thyroxine level

increased carbon dioxide production

increased oxygen consumption

decreased respiratory quotient

abnormal glucose homeostasis

abnormal gluconeogenesis

improved glucose tolerance

increased insulin sensitivity

increased circulating adiponectin level

decreased liver triglyceride level

increased basal metabolism

Availability

Mouse Genotype

Akt1^tm1Mbb/Akt1^tm1Mbb

Akt1^tm2.1Mbb/Akt1^tm2.1Mbb

Akt1^tm2Mbb/Akt1^tm2Mbb
Tg(Nes-cre)1Kln/0 (conditional)

Akt1^tm2Mbb/Akt1^tm2Mbb
Tg(Ckmm-cre)5Khn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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