Symbol
Name
ID

Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
MGI:1353495

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Decreased activity of mitochondrial complex I

Decreased activity of mitochondrial complex II

Decreased activity of mitochondrial complex III

Decreased activity of mitochondrial complex IV

Hyperalaninemia

Elevated circulating creatine kinase concentration

Highly elevated creatine kinase

Increased CSF lactate

Increased circulating lactate concentration

Lactic acidosis

Severe lactic acidosis

3-Methylglutaconic aciduria

Ketonuria

Myoglobinuria

Organic aciduria

Exercise intolerance

Disease(s) Associated with SLC25A4

autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2

mitochondrial DNA depletion syndrome 12a

mitochondrial DNA depletion syndrome 12b

mitochondrial myopathy

Mouse Phenotypes		increased circulating alanine level	abnormal blood homeostasis	increased blood urea nitrogen level	increased circulating insulin level	increased circulating lactate level	increased circulating calcium level	increased circulating alkaline phosphatase level	improved glucose tolerance	decreased circulating chloride level	abnormal exercise endurance
Availability	Mouse Genotype	increased circulating alanine level	abnormal blood homeostasis	increased blood urea nitrogen level	increased circulating insulin level	increased circulating lactate level	increased circulating calcium level	increased circulating alkaline phosphatase level	improved glucose tolerance	decreased circulating chloride level	abnormal exercise endurance
	Slc25a4^{tm1a(EUCOMM)Wtsi}/Slc25a4^{tm1a(EUCOMM)Wtsi}
	Slc25a4^tm2Dwa/Slc25a4^tm2Dwa

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23