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Symbol Name ID |
Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit MGI:1336173 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Type II diabetes mellitus |
Insulin resistance |
| Disease(s) Associated with PRKAA2 | ||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased insulin secretion |
increased susceptibility to diet-induced obesity |
decreased circulating fructosamine level |
decreased fasting circulating glucose level |
increased circulating glucose level |
hyperglycemia |
decreased circulating insulin level |
increased circulating insulin level |
decreased circulating leptin level |
increased circulating leptin level |
increased circulating free fatty acids level |
increased circulating alanine transaminase level |
decreased circulating alkaline phosphatase level |
increased circulating aspartate transaminase level |
increased circulating creatine kinase level |
decreased circulating serum albumin level |
abnormal urine catecholamine level |
abnormal glucose homeostasis |
abnormal gluconeogenesis |
impaired glucose tolerance |
abnormal glycogen homeostasis |
decreased skeletal muscle glycogen level |
insulin resistance |
increased circulating adiponectin level |
increased fatty acids level |
increased triglyceride level |
abnormal metabolism |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||
| Prkaa2tm1.1Vio/Prkaa2tm1.1Vio | * | ||||||||||||||||||||||||||||
| Prkaa2tm1b(EUCOMM)Hmgu/Prkaa2tm1b(EUCOMM)Hmgu | |||||||||||||||||||||||||||||
| Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Alb1-cre)7Gsc/0 (conditional) |
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| Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Pomc1-cre)1Gsb/0 (conditional) |
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| Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Agrp-cre)1Gsb/0 (conditional) |
* | ||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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