Symbol Name ID |
Wfs1
wolframin ER transmembrane glycoprotein MGI:1328355 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Diabetes mellitus |
Basal ganglia calcification |
Disease(s) Associated with WFS1 | ||
optic atrophy | ||
Wolfram syndrome |
Mouse Phenotypes | homeostasis/metabolism phenotype |
increased glucagon secretion |
decreased insulin secretion |
abnormal blood homeostasis |
decreased circulating glucose level |
increased circulating glucose level |
hyperglycemia |
increased circulating corticosterone level |
decreased circulating insulin level |
increased circulating insulin-like growth factor I level |
decreased circulating leptin level |
increased oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
|
Availability | Mouse Genotype | ||||||||||||||
Wfs1tm1Koks/Wfs1tm1Koks | * | ||||||||||||||
Wfs1tm1Yoka/Wfs1tm1Yoka | |||||||||||||||
Wfs1tm1Koks/Wfs1+ | |||||||||||||||
Wfs1tm1Perm/Wfs1tm1Perm Tg(Ins2-cre)23Herr/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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