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Symbol
Name
ID
Sqstm1
sequestosome 1
MGI:107931
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Elevated circulating creatine kinase concentration
Elevated circulating alkaline phosphatase concentration
Disease(s) Associated with SQSTM1
distal myopathy with rimmed vacuoles
Paget's disease of bone 3

Mouse Phenotypes
homeostasis/metabolism phenotype
increased circulating creatinine level
increased blood urea nitrogen level
decreased circulating glucose level
hypoglycemia
hyperglycemia
increased circulating leptin level
increased circulating cholesterol level
increased circulating aspartate transaminase level
decreased core body temperature
decreased energy expenditure
decreased oxygen consumption
impaired glucose tolerance
insulin resistance
Availability Mouse Genotype
Sqstm1tm1a(KOMP)Wtsi/Sqstm1tm1a(KOMP)Wtsi
Sqstm1tm1Hwl/Sqstm1tm1Hwl
Sqstm1tm1Keta/Sqstm1tm1Keta
Sqstm1em1Kmts/Sqstm1+
Sqstm1tm2.1Jmos/Sqstm1tm2.1Jmos
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
*
Sqstm1tm2.1Jmos/Sqstm1tm2.1Jmos
Tg(Fabp4-cre)1Rev/0  (conditional)
Sqstm1tm2.1Jmos/Sqstm1tm2.1Jmos
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory