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Symbol Name ID |
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11 MGI:107501 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Maternal diabetes |
Reduced C-peptide level |
Hyperglycemia |
Hypoglycemia |
Diabetes mellitus |
Maturity-onset diabetes of the young |
Type I diabetes mellitus |
Type II diabetes mellitus |
Hyperinsulinemic hypoglycemia |
Insulin resistance |
| Disease(s) Associated with KCNJ11 | ||||||||||
| familial hyperinsulinemic hypoglycemia 2 | ||||||||||
| maturity-onset diabetes of the young type 13 | ||||||||||
| permanent neonatal diabetes mellitus | ||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased aerobic running capacity |
decreased glucagon secretion |
decreased insulin secretion |
increased insulin secretion |
decreased susceptibility to diet-induced obesity |
abnormal circulating glucose level |
decreased fasting circulating glucose level |
hypoglycemia |
increased circulating glucose level |
hyperglycemia |
increased circulating atrial natriuretic factor |
abnormal circulating glucagon level |
decreased circulating glucagon level |
increased circulating glucagon level |
decreased circulating insulin level |
increased circulating insulin level |
increased energy expenditure |
increased oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
improved glucose tolerance |
increased insulin sensitivity |
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| Availability | Mouse Genotype | |||||||||||||||||||||||
| Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi | ||||||||||||||||||||||||
| Kcnj11tm1Sse/Kcnj11tm1Sse | ||||||||||||||||||||||||
| Kcnj11tm1Sse/Kcnj11tm1Sse Tg(Ins1-Kcnj11*)#Nich/? |
* | |||||||||||||||||||||||
| Kcnj11Y12stop/Kcnj11Y12stop | ||||||||||||||||||||||||
| Kcnj11tm1Sse/Kcnj11+ Tg(Ins1-Kcnj11*)#Nich/? |
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| Tg(Ins1-Kcnj11*)#Nich/? | ||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+ Tg(Ins2-cre)23Herr/0 (conditional) |
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| Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+ Tg(Ins2-cre)23Herr/0 (conditional) |
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| Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+ Tg(Pdx1-cre/Esr1*)#Dam/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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