|
Symbol Name ID |
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1 MGI:103562 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Elevated circulating creatinine concentration |
Elevated circulating hepatic transaminase concentration |
Type I diabetes mellitus |
Type II diabetes mellitus |
Insulin resistance |
Edema |
Pulmonary edema |
Proteinuria |
Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio |
| Disease(s) Associated with HSD11B1 | |||||||||
| cortisone reductase deficiency 2 | |||||||||
| pre-eclampsia | |||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased circulating glucose level |
decreased circulating corticosterone level |
increased circulating corticosterone level |
abnormal circulating insulin level |
decreased circulating insulin level |
abnormal circulating cholesterol level |
increased circulating HDL cholesterol level |
decreased circulating LDL cholesterol level |
increased circulating cholesterol level |
decreased circulating triglyceride level |
abnormal amniotic fluid composition |
abnormal glucose homeostasis |
abnormal glucose tolerance |
improved glucose tolerance |
increased liver glycogen level |
abnormal corticosterone level |
abnormal lipid homeostasis |
decreased collagen level |
abnormal enzyme/coenzyme activity |
|
| Availability | Mouse Genotype | ||||||||||||||||||||
| Hsd11b1tm1.1Awhi/Hsd11b1tm1.1Awhi | * | ||||||||||||||||||||
| Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla | |||||||||||||||||||||
| Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck | * | ||||||||||||||||||||
| Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi | |||||||||||||||||||||
| Hsd11b1tm1Yko/Hsd11b1tm1Yko | |||||||||||||||||||||
| Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1+ | |||||||||||||||||||||
| Hsd11b1tm1.2Awhi/Hsd11b1tm1.2Awhi Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||||||||||
| Hsd11b1tm1Ggla/Hsd11b1tm1Ggla Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
* | ||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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