Symbol Name ID |
Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor MGI:103076 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA level |
Increased circulating IgM level |
Abnormality of metabolism/homeostasis |
Hypocalcemic seizures |
Hypophosphatemia |
Conjugated hyperbilirubinemia |
Abnormal circulating lipid concentration |
Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypertriglyceridemia |
Hypoalbuminemia |
Elevated circulating C-reactive protein concentration |
Elevated gamma-glutamyltransferase level |
Elevated circulating alkaline phosphatase concentration |
Decreased alpha-galactosidase A activity |
Elevated erythrocyte sedimentation rate |
Glucose intolerance |
Diabetes mellitus |
Type II diabetes mellitus |
Impaired glucose tolerance |
Joint swelling |
Lymphedema |
Fever |
Food intolerance |
High serum calcitriol |
Elevated circulating globotriaosylceramide concentration |
Urinary mulberry cells |
Decreased level of D-mannose in urine |
Proteinuria |
Lipiduria |
Elevated circulating parathyroid hormone level |
Ascites |
Increased circulating free T3 |
Increased circulating free T4 concentration |
Decreased thyroid-stimulating hormone level |
Disease(s) Associated with VDR | |||||||||||||||||||||||||||||||||||
atopic dermatitis | |||||||||||||||||||||||||||||||||||
Behcet's disease | |||||||||||||||||||||||||||||||||||
coronary artery disease | |||||||||||||||||||||||||||||||||||
Fabry disease | |||||||||||||||||||||||||||||||||||
Graves' disease | |||||||||||||||||||||||||||||||||||
polycystic ovary syndrome | |||||||||||||||||||||||||||||||||||
primary biliary cholangitis | |||||||||||||||||||||||||||||||||||
rheumatoid arthritis | |||||||||||||||||||||||||||||||||||
vitamin D-dependent rickets type 2A |
Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal blood homeostasis |
increased circulating angiotensin II level |
increased circulating atrial natriuretic factor |
increased circulating follicle stimulating hormone level |
increased circulating luteinizing hormone level |
increased circulating parathyroid hormone level |
decreased circulating calcium level |
decreased circulating phosphate level |
increased circulating phosphate level |
increased circulating angiotensinogen level |
increased circulating alkaline phosphatase level |
increased circulating renin level |
abnormal nitric oxide homeostasis |
abnormal glucose tolerance |
increased urine potassium level |
increased urine sodium level |
abnormal vitamin D level |
abnormal mineral homeostasis |
abnormal interleukin level |
abnormal tumor necrosis factor level |
abnormal urine homeostasis |
increased urine calcium level |
abnormal response to vitamins |
abnormal fat-soluble vitamin level |
abnormal enzyme/coenzyme activity |
abnormal renin activity |
increased renin activity |
increased susceptibility to xenobiotic induced morbidity/mortality |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||
Vdrtm1.1Gcm/Vdrtm1.1Gcm | ||||||||||||||||||||||||||||||
Vdrtm1.2Sgcg/Vdrtm1.2Sgcg | ||||||||||||||||||||||||||||||
Vdrtm1Mbd/Vdrtm1Mbd | ||||||||||||||||||||||||||||||
Vdrtm1Rge/Vdrtm1Rge | ||||||||||||||||||||||||||||||
Vdrtm1Ska/Vdrtm1Ska | ||||||||||||||||||||||||||||||
Vdrtm1Tyam/Vdrtm1Tyam | ||||||||||||||||||||||||||||||
Vdrtm2.1Ska/Vdrtm2.1Ska | ||||||||||||||||||||||||||||||
Vdrtm1Gcm/Vdrtm1Gcm Tg(Col2a1-cre)1Bhr/? (conditional) |
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Tg(Col1a1-cre)1Kry/0 Vdrtm2Ska/Vdrtm2Ska (conditional) |
* | |||||||||||||||||||||||||||||
Vdrtm1.1Sgcg/Vdrtm1.2Sgcg Myl2tm1(cre)Krc/Myl2+ (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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