Symbol
Name
ID

H2-Ab1
histocompatibility 2, class II antigen A, beta 1
MGI:103070

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Polyclonal elevation of IgM

Decreased circulating antibody level

Secretory IgA deficiency

Abnormal erythrocyte enzyme concentration or activity

Abnormality of metabolism/homeostasis

Hypercalcemia

Hyperkalemia

Hyponatremia

Abnormality of iron homeostasis

Decreased circulating iron concentration

Decreased level of 1,5 anhydroglucitol in serum

Unconjugated hyperbilirubinemia

Increased blood urea nitrogen

Elevated circulating creatinine concentration

Hypoalbuminemia

Elevated circulating C-reactive protein concentration

Reduced haptoglobin level

Increased CSF protein concentration

Elevated circulating hepatic transaminase concentration

Increased circulating lactate dehydrogenase concentration

Elevated alkaline phosphatase of hepatic origin

Reduced leukocyte alkaline phosphatase

Elevated erythrocyte sedimentation rate

Hyperglycemia

Hypoglycemia

Diabetes mellitus

Type I diabetes mellitus

Type II diabetes mellitus

Increased circulating lactate concentration

Ketoacidosis

Renal Fanconi syndrome

Edema

Joint swelling

Pleural effusion

Chylothorax

Pulmonary edema

Abnormality of temperature regulation

Fever

Hypothermia

Reduced circulating vitamin A concentration

Decreased circulating vitamin E concentration

Decreased circulating vitamin D concentration

Decreased circulating vitamin K concentration

Hypercalciuria

Hematuria

Microscopic hematuria

Pyuria

Glycosuria

Decreased level of D-mannose in urine

Proteinuria

Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria

Hemosiderinuria

Ascites

Increased circulating free T3

Increased circulating free T4 concentration

Decreased thyroid-stimulating hormone level

Atypical scarring of skin

Scarring

Disease(s) Associated with HLA-DQB1

Addison's disease

autoimmune polyendocrine syndrome type 2

Behcet's disease

beta thalassemia

chronic myeloid leukemia

common variable immunodeficiency

Creutzfeldt-Jakob disease

Graves' disease

IgA glomerulonephritis

immunoglobulin alpha deficiency

narcolepsy

paroxysmal nocturnal hemoglobinuria

pemphigus vulgaris

pre-eclampsia

primary sclerosing cholangitis

rheumatoid arthritis

sarcoidosis

sickle cell anemia

Sjogren's syndrome

systemic lupus erythematosus

thrombotic thrombocytopenic purpura

type 1 diabetes mellitus

Mouse Phenotypes		increased urine protein level	abnormal response/metabolism to endogenous compounds
Availability	Mouse Genotype
	H2-Ab1^bm12/H2-Ab1^bm12

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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