|
Symbol Name ID |
Cav1
caveolin 1, caveolae protein MGI:102709 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormality of chromosome stability |
Chromosome breakage |
Pedal edema |
Hypocalcemia |
Hypercholesterolemia |
Hypertriglyceridemia |
Diabetes mellitus |
Insulin resistance |
Hepatic steatosis |
| Disease(s) Associated with CAV1 | |||||||||
| congenital generalized lipodystrophy type 3 | |||||||||
| primary pulmonary hypertension | |||||||||
| systemic scleroderma |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
impaired exercise endurance |
abnormal vascular wound healing |
abnormal cellular cholesterol metabolism |
decreased susceptibility to diet-induced obesity |
amyloid beta deposits |
abnormal homeostasis |
impaired adaptive thermogenesis |
abnormal circulating amino acid level |
abnormal blood homeostasis |
increased blood urea nitrogen level |
decreased circulating glucose level |
hyperglycemia |
increased circulating insulin level |
decreased circulating leptin level |
increased circulating HDL cholesterol level |
increased circulating cholesterol level |
abnormal circulating free fatty acids level |
decreased circulating glycerol level |
increased circulating glycerol level |
increased circulating triglyceride level |
increased circulating VLDL triglyceride level |
increased circulating CXCL10 level |
increased circulating interferon-gamma level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
decreased core body temperature |
pulmonary edema |
abnormal nitric oxide homeostasis |
increased oxygen consumption |
abnormal respiratory quotient |
increased respiratory quotient |
abnormal glucose homeostasis |
enhanced gluconeogenesis |
decreased liver glycogen level |
increased liver glycogen level |
insulin resistance |
decreased circulating adiponectin level |
abnormal renal calcium reabsorption |
abnormal lipid homeostasis |
abnormal lipid level |
abnormal free fatty acids level |
decreased fatty acids level |
abnormal triglyceride level |
decreased liver triglyceride level |
increased triglyceride level |
abnormal cytokine level |
increased urine calcium level |
enhanced lipolysis |
impaired lipolysis |
increased incidence of tumors by chemical induction |
increased cerebral infarct size |
impaired wound healing |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cav1em2(IMPC)Ics/Cav1em2(IMPC)Ics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cav1tm1Krc/Cav1tm1Krc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cav1tm1Kur/Cav1tm1Kur | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cav1tm1Mls/Cav1tm1Mls | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cav1tm1Tt/Cav1tm1Tt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cav1tm1Pesch/Cav1tm1Pesch Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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