Symbol
Name
ID

Jak3
Janus kinase 3
MGI:99928

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Juvenile myelomonocytic leukemia
Disease(s) Associated with JAK3	Juvenile myelomonocytic leukemia
juvenile myelomonocytic leukemia

Mouse Phenotypes

abnormal dendritic cell differentiation

abnormal T cell proliferation

decreased T cell proliferation

abnormal thymus morphology

abnormal thymus cell ratio

absent Hassall's corpuscle

abnormal thymus cortex morphology

thymus cortex hypoplasia

abnormal thymus corticomedullary boundary morphology

abnormal thymus medulla morphology

small thymus medulla

decreased thymus weight

small thymus

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal hematopoietic system morphology/development

abnormal erythropoiesis

abnormal lymphopoiesis

abnormal B cell differentiation

decreased immature B cell number

arrested B cell differentiation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal myelopoiesis

impaired hematopoiesis

increased neutrophil cell number

decreased myeloid dendritic cell number

increased myeloid dendritic cell number

decreased dendritic cell number

decreased mature B cell number

decreased B-1 B cell number

decreased B-2 B cell number

decreased memory B cell number

increased B-1b cell number

increased memory B cell number

decreased B cell number

absent B cells

decreased pre-B cell number

increased B cell number

decreased NK cell number

absent NK cells

abnormal T cell subpopulation ratio

abnormal T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased T cell number

decreased single-positive T cell number

increased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

decreased hematopoietic stem cell number

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal lymphocyte morphology

abnormal B cell morphology

abnormal T cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal spleen morphology

decreased spleen weight

small spleen

spleen hypoplasia

abnormal spleen white pulp morphology

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal splenic cell ratio

abnormal leukocyte physiology

abnormal lymphocyte physiology

increased IgE level

decreased IgG level

decreased IgM level

abnormal T cell physiology

abnormal T cell activation

Availability

Mouse Genotype

Jak3^bfy/Jak3^bfy

Jak3^m1Btlr/Jak3^m1Btlr

Jak3^m1J/Jak3^m1J

Jak3^M1Pgrs/Jak3^M1Pgrs

Jak3^m2Btlr/Jak3^m2Btlr

Jak3^m3Btlr/Jak3^m3Btlr

Jak3^m4Btlr/Jak3^m4Btlr

Jak3^M5Btlr/Jak3^M5Btlr

Jak3^m6Btlr/Jak3^m6Btlr

Jak3^M7Btlr/Jak3^M7Btlr

Jak3^m8Btlr/Jak3^m8Btlr

Jak3^tm1Flv/Jak3^tm1Flv

Jak3^tm1Ljb/Jak3^tm1Ljb

Jak3^tm1Ljb/Jak3^tm1Ljb
Tg(Lck-Jak3)1Ljb/0

Jak3^tm1Ljb/Jak3^tm1Ljb
Tg(Lck-Jak3)2Ljb/0

Jak3^tm1Tks/Jak3^tm1Tks

Jak3^wil/Jak3^wil

Jak3^X887Y/Jak3^X887Y

Jak3^em1(IMPC)Mbp/Jak3⁺

Jak3^tm1Ljb/Jak3⁺

Jak3^tm1Tks/Jak3⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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