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Symbol
Name
ID 		Ccl7
C-C motif chemokine ligand 7
MGI:99512
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA concentration
Increased circulating IgE concentration
Abnormal bleeding
Epistaxis
Gingival bleeding
Gastrointestinal hemorrhage
Joint hemorrhage
Menorrhagia
Persistent bleeding after trauma
Prolonged bleeding time
Bruising susceptibility
Purpura
Petechiae
Spontaneous hematomas
Abnormal megakaryocyte morphology
Increased megakaryocyte colony forming unit count
Megakaryocytopenia
Anemia
Hemolytic anemia
Anemia of inadequate production
Poikilocytosis
Acanthocytosis
Decreased total leukocyte count
Increased total leukocyte count
Abnormal thrombosis
Arterial thrombosis
Superficial thrombophlebitis
Hyperfibrinogenemia
Abnormality of thrombocytes
Thrombocytopenia
Congenital thrombocytopenia
Intermittent thrombocytopenia
Abnormal platelet shape
Abnormal platelet volume
Decreased mean platelet volume
Elevated erythrocyte sedimentation rate
Splenomegaly
Disease(s) Associated with CCL2
Behcet's disease
IgA vasculitis
pancreatitis
systemic lupus erythematosus
temporal arteritis
thrombocytopenia

Mouse Phenotypes
abnormal dendritic cell chemotaxis
abnormal macrophage chemotaxis
impaired macrophage chemotaxis
abnormal leukocyte migration
abnormal microglial cell physiology
decreased eosinophil cell number
increased neutrophil cell number
decreased dendritic cell number
increased CD4-positive, alpha-beta T cell number
decreased lymphocyte cell number
decreased macrophage cell number
increased osteoclast cell number
decreased leukocyte cell number
abnormal monocyte morphology
impaired eosinophil recruitment
abnormal neutrophil physiology
increased IgG1 level
increased IgG level
abnormal T cell physiology
abnormal macrophage physiology
Availability Mouse Genotype
Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Ccl2tm1Lex/Ccl2tm1Lex *
Ccl2tm1Rol/Ccl2tm1Rol
Ccl2tm1Rol/Ccl2tm1Rol
Tg(Ccr2-EGFP)8Pame/0
Ccl7tm1Ifc/Ccl7tm1Ifc
Ccl11tm1Mer/Ccl11tm1Mer
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Nes-cre)1Kln/0  (conditional)
Ccl2tm1.1Pame/Ccl2tm1.1Pame
Tg(Tek-cre)12Flv/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory